DegronMD

Uniprot ID: Q8WXR4

Source protein: Myosin-IIIb

Source gene: MYO3B

Class: SCF_FBXL2

Location: 1094:1104

E3 ligase: FBXL2

DEGRON score: 0.8229

ASA_SCORE: 28.6091

COIL: 0.003

CONS_SCORE: 0.6091

DSS_SCORE: 0.3557

HELIX: 0.9967

FCONS_SCORE: 1.4116

RIG_SCORE: 0.8147

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1104W	TCGA-19-5956	GBM	TCGA	IQSAWRGYDAR	SCF_FBXL2	0.8634
p.R1104W	SIDM00628	Breast Carcinoma	GDSC	IQSAWRGYDAR	SCF_FBXL2	0.8634
p.R1104W	MDA-MB-468	breast	COSMIC	IQSAWRGYDAR	SCF_FBXL2	0.8634
p.K1109R	TCGA-32-2491	GBM	TCGA	IQSAWRGYDAR	SCF_FBXL2	0.3056
p.E1088V	TCGA-AD-6964	COAD	TCGA	IQSAWRGYDAR	SCF_FBXL2	0.1667
p.E1088V	DO8360	COAD	ICGC	IQSAWRGYDAR	SCF_FBXL2	0.1667
p.E1085K	TCGA-BH-A18P	BRCA	TCGA	IQSAWRGYDAR	SCF_FBXL2	0.0833
p.E1085K	DO3346	BRCA	ICGC	IQSAWRGYDAR	SCF_FBXL2	0.0833
p.E1085V	TCGA-BH-A18P	BRCA	TCGA	IQSAWRGYDAR	SCF_FBXL2	0.0833
p.E1085V	DO3346	BRCA	ICGC	IQSAWRGYDAR	SCF_FBXL2	0.0833
p.G1100E	TCGA-EB-A4XL	SKCM	TCGA	IQSAWRGYDAR	SCF_FBXL2	0.7199
p.W1098C	TCGA-G3-A25W	LIHC	TCGA	IQSAWRGYDAR	SCF_FBXL2	0.5889
p.I1110M	TCGA-GN-A266	SKCM	TCGA	IQSAWRGYDAR	SCF_FBXL2	0.1667
p.A1111T	DO9114	COAD	ICGC	IQSAWRGYDAR	SCF_FBXL2	0.1389
p.A1111T	DO38703	STAD	ICGC	IQSAWRGYDAR	SCF_FBXL2	0.1389
p.Q1095R	DO8264	COAD	ICGC	IQSAWRGYDAR	SCF_FBXL2	0.7329
p.T1099A	DO234462	ESAD	ICGC	IQSAWRGYDAR	SCF_FBXL2	0.7139
p.R1113Q	DO233090	GACA	ICGC	IQSAWRGYDAR	SCF_FBXL2	0.0833
p.R1113W	DO13863	GBM	ICGC	IQSAWRGYDAR	SCF_FBXL2	0.0833
p.K1086N	DO229029	LICA	ICGC	IQSAWRGYDAR	SCF_FBXL2	0.2222
p.W1107C	DO22970	LIHC	ICGC	IQSAWRGYDAR	SCF_FBXL2	0.25
p.T1114M	DO219165	LUSC	ICGC	IQSAWRGYDAR	SCF_FBXL2	0.0556
p.G1109E	DO222824	MELA	ICGC	IQSAWRGYDAR	SCF_FBXL2	0.3056
p.G1109E	DO47401	SKCM	ICGC	IQSAWRGYDAR	SCF_FBXL2	0.3056
p.P1109S	DO222837	MELA	ICGC	IQSAWRGYDAR	SCF_FBXL2	0.3056
p.P1109S	NB10	autonomic_ganglia	COSMIC	IQSAWRGYDAR	SCF_FBXL2	0.3056
p.E1085D	DO232832	NACA	ICGC	IQSAWRGYDAR	SCF_FBXL2	0.0833
p.G1113D	DO37911	SKCM	ICGC	IQSAWRGYDAR	SCF_FBXL2	0.0833
p.D1098G	DO41331	UCEC	ICGC	IQSAWRGYDAR	SCF_FBXL2	0.7198
p.A1091V	SIDM00958	Chronic Myelogenous Leukemia	GDSC	IQSAWRGYDAR	SCF_FBXL2	0.25
p.A1091V	ACH-000920	Leukemia	CCLE	IQSAWRGYDAR	SCF_FBXL2	0.25
p.A1091V	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	IQSAWRGYDAR	SCF_FBXL2	0.25
p.A1112S	NCI-H1838	lung	COSMIC	IQSAWRGYDAR	SCF_FBXL2	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IQSAWRGYDAR

Degron related mutations and impact score

Drug responses associated with MYO3B mutations

All proteins holding degron of IQSAWRGYDAR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXR4	Myosin-IIIb	SCF_FBXL2	1094:1104	IQSAWRGYDAR	FBXL2	0.8229	More...