DegronMD - Q8WY21(SORCS1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D1041N	TCGA-18-3409	LUSC	TCGA	VLPYQD	LIG_APCC_ABBA_1	1036:1041	Mutation altering degron motif	0.6932
p.D1041N	DO26444	LUSC	ICGC	VLPYQD	LIG_APCC_ABBA_1	1036:1041	Mutation altering degron motif	0.6932
p.P1026T	TCGA-44-8117	LUAD	TCGA	VLPYQD	LIG_APCC_ABBA_1	1036:1041	Mutation rewiring degron network	0.0556
p.P1026T	DO24028	LUAD	ICGC	VLPYQD	LIG_APCC_ABBA_1	1036:1041	Mutation rewiring degron network	0.0556
p.P1026A	TCGA-50-5049	LUAD	TCGA	VLPYQD	LIG_APCC_ABBA_1	1036:1041	Mutation rewiring degron network	0.0556
p.P1026A	DO23705	LUAD	ICGC	VLPYQD	LIG_APCC_ABBA_1	1036:1041	Mutation rewiring degron network	0.0556
p.L1037I	TCGA-50-6595	LUAD	TCGA	VLPYQD	LIG_APCC_ABBA_1	1036:1041	Mutation altering degron motif	0.6063
p.L1037I	DO23654	LUAD	ICGC	VLPYQD	LIG_APCC_ABBA_1	1036:1041	Mutation altering degron motif	0.6063
p.P1038S	TCGA-AX-A05S	UCEC	TCGA	VLPYQD	LIG_APCC_ABBA_1	1036:1041	Mutation altering degron motif	0.6752
p.P1038S	DO43218	UCEC	ICGC	VLPYQD	LIG_APCC_ABBA_1	1036:1041	Mutation altering degron motif	0.6752
p.L1037Q	TCGA-AX-A2H4	UCEC	TCGA	VLPYQD	LIG_APCC_ABBA_1	1036:1041	Mutation altering degron motif	0.6654
p.L1037Q	DO41193	UCEC	ICGC	VLPYQD	LIG_APCC_ABBA_1	1036:1041	Mutation altering degron motif	0.6654
p.A1043D	TCGA-B5-A11G	UCEC	TCGA	VLPYQD	LIG_APCC_ABBA_1	1036:1041	Mutation rewiring degron network	0.2778
p.A1043D	DO43514	UCEC	ICGC	VLPYQD	LIG_APCC_ABBA_1	1036:1041	Mutation rewiring degron network	0.2778
p.A1043D	SIDM00833	Colorectal Carcinoma	GDSC	VLPYQD	LIG_APCC_ABBA_1	1036:1041	Mutation rewiring degron network	0.2778
p.A1043D	ACH-000421	Colon/Colorectal Cancer	CCLE	VLPYQD	LIG_APCC_ABBA_1	1036:1041	Mutation rewiring degron network	0.2778
p.A1043D	SW837	large intestine	COSMIC	VLPYQD	LIG_APCC_ABBA_1	1036:1041	Mutation rewiring degron network	0.2778
p.P1042Q	TCGA-FS-A1ZJ	SKCM	TCGA	VLPYQD	LIG_APCC_ABBA_1	1036:1041	Mutation rewiring degron network	0.3056
p.P1042Q	DO37956	SKCM	ICGC	VLPYQD	LIG_APCC_ABBA_1	1036:1041	Mutation rewiring degron network	0.3056
p.P1042L	TCGA-GN-A266	SKCM	TCGA	VLPYQD	LIG_APCC_ABBA_1	1036:1041	Mutation rewiring degron network	0.3056
p.P1042L	DO37432	SKCM	ICGC	VLPYQD	LIG_APCC_ABBA_1	1036:1041	Mutation rewiring degron network	0.3056
p.L1028V	DO234148	ESAD	ICGC	VLPYQD	LIG_APCC_ABBA_1	1036:1041	Mutation rewiring degron network	0.1111
p.R1048S	DO234266	ESAD	ICGC	VLPYQD	LIG_APCC_ABBA_1	1036:1041	Mutation rewiring degron network	0.1389
p.R1048S	DO233101	GACA	ICGC	VLPYQD	LIG_APCC_ABBA_1	1036:1041	Mutation rewiring degron network	0.1389
p.P1029T	DO229031	LICA	ICGC	VLPYQD	LIG_APCC_ABBA_1	1036:1041	Mutation rewiring degron network	0.1389
p.T1031P	DO27839	MALY	ICGC	VLPYQD	LIG_APCC_ABBA_1	1036:1041	Mutation rewiring degron network	0.1944
p.D1041G	DO228322	MALY	ICGC	VLPYQD	LIG_APCC_ABBA_1	1036:1041	Mutation altering degron motif	0.7198
p.D1041G	SIDM01247	Burkitt's Lymphoma	GDSC	VLPYQD	LIG_APCC_ABBA_1	1036:1041	Mutation altering degron motif	0.7198
p.D1041G	ACH-001636	Lymphoma	CCLE	VLPYQD	LIG_APCC_ABBA_1	1036:1041	Mutation altering degron motif	0.7198
p.D1041G	ACH-002300	Lymphoma	CCLE	VLPYQD	LIG_APCC_ABBA_1	1036:1041	Mutation altering degron motif	0.7198
p.D1041G	Ramos-2G6-4C10	haematopoietic and lymphoid tissue	COSMIC	VLPYQD	LIG_APCC_ABBA_1	1036:1041	Mutation altering degron motif	0.7198
p.P1042R	SIDM01591	Breast Carcinoma	GDSC	VLPYQD	LIG_APCC_ABBA_1	1036:1041	Mutation rewiring degron network	0.3056
p.P1042R	ACH-000540	Non-Cancerous	CCLE	VLPYQD	LIG_APCC_ABBA_1	1036:1041	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SORCS1

UniProt ID: Q8WY21

Entrez ID: 114815

Protein name: VPS10 domain-containing receptor SorCS1 (hSorCS)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SORCS1 in