DegronMD

Uniprot ID: Q8WY21

Source protein: VPS10 domain-containing receptor SorCS1

Source gene: SORCS1

Class: LIG_APCC_ABBA_1

Location: 1036:1041

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9451

ASA_SCORE: 54.55

COIL: 0.6347

CONS_SCORE: 0.2093

DSS_SCORE: 0.4017

HELIX: 0.0078

FCONS_SCORE: 0.9117

RIG_SCORE: 0.829

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1041N	TCGA-18-3409	LUSC	TCGA	VLPYQD	LIG_APCC_ABBA_1	0.6932
p.D1041N	DO26444	LUSC	ICGC	VLPYQD	LIG_APCC_ABBA_1	0.6932
p.P1026T	TCGA-44-8117	LUAD	TCGA	VLPYQD	LIG_APCC_ABBA_1	0.0556
p.P1026T	DO24028	LUAD	ICGC	VLPYQD	LIG_APCC_ABBA_1	0.0556
p.P1026A	TCGA-50-5049	LUAD	TCGA	VLPYQD	LIG_APCC_ABBA_1	0.0556
p.P1026A	DO23705	LUAD	ICGC	VLPYQD	LIG_APCC_ABBA_1	0.0556
p.L1037I	TCGA-50-6595	LUAD	TCGA	VLPYQD	LIG_APCC_ABBA_1	0.6063
p.L1037I	DO23654	LUAD	ICGC	VLPYQD	LIG_APCC_ABBA_1	0.6063
p.P1038S	TCGA-AX-A05S	UCEC	TCGA	VLPYQD	LIG_APCC_ABBA_1	0.6752
p.P1038S	DO43218	UCEC	ICGC	VLPYQD	LIG_APCC_ABBA_1	0.6752
p.L1037Q	TCGA-AX-A2H4	UCEC	TCGA	VLPYQD	LIG_APCC_ABBA_1	0.6654
p.L1037Q	DO41193	UCEC	ICGC	VLPYQD	LIG_APCC_ABBA_1	0.6654
p.A1043D	TCGA-B5-A11G	UCEC	TCGA	VLPYQD	LIG_APCC_ABBA_1	0.2778
p.A1043D	DO43514	UCEC	ICGC	VLPYQD	LIG_APCC_ABBA_1	0.2778
p.A1043D	SIDM00833	Colorectal Carcinoma	GDSC	VLPYQD	LIG_APCC_ABBA_1	0.2778
p.A1043D	ACH-000421	Colon/Colorectal Cancer	CCLE	VLPYQD	LIG_APCC_ABBA_1	0.2778
p.A1043D	SW837	large_intestine	COSMIC	VLPYQD	LIG_APCC_ABBA_1	0.2778
p.P1042Q	TCGA-FS-A1ZJ	SKCM	TCGA	VLPYQD	LIG_APCC_ABBA_1	0.3056
p.P1042Q	DO37956	SKCM	ICGC	VLPYQD	LIG_APCC_ABBA_1	0.3056
p.P1042L	TCGA-GN-A266	SKCM	TCGA	VLPYQD	LIG_APCC_ABBA_1	0.3056
p.P1042L	DO37432	SKCM	ICGC	VLPYQD	LIG_APCC_ABBA_1	0.3056
p.L1028V	DO234148	ESAD	ICGC	VLPYQD	LIG_APCC_ABBA_1	0.1111
p.R1048S	DO234266	ESAD	ICGC	VLPYQD	LIG_APCC_ABBA_1	0.1389
p.R1048S	DO233101	GACA	ICGC	VLPYQD	LIG_APCC_ABBA_1	0.1389
p.P1029T	DO229031	LICA	ICGC	VLPYQD	LIG_APCC_ABBA_1	0.1389
p.T1031P	DO27839	MALY	ICGC	VLPYQD	LIG_APCC_ABBA_1	0.1944
p.D1041G	DO228322	MALY	ICGC	VLPYQD	LIG_APCC_ABBA_1	0.7198
p.D1041G	SIDM01247	Burkitt's Lymphoma	GDSC	VLPYQD	LIG_APCC_ABBA_1	0.7198
p.D1041G	ACH-001636	Lymphoma	CCLE	VLPYQD	LIG_APCC_ABBA_1	0.7198
p.D1041G	ACH-002300	Lymphoma	CCLE	VLPYQD	LIG_APCC_ABBA_1	0.7198
p.D1041G	Ramos-2G6-4C10	haematopoietic_and_lymphoid_tissue	COSMIC	VLPYQD	LIG_APCC_ABBA_1	0.7198
p.P1042R	SIDM01591	Breast Carcinoma	GDSC	VLPYQD	LIG_APCC_ABBA_1	0.3056
p.P1042R	ACH-000540	Non-Cancerous	CCLE	VLPYQD	LIG_APCC_ABBA_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VLPYQD

Degron related mutations and impact score

Drug responses associated with SORCS1 mutations

All proteins holding degron of VLPYQD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WY21	VPS10 domain-containing receptor SorCS1	LIG_APCC_ABBA_1	1036:1041	VLPYQD	APC,CDC20,FZR1	0.9451	More...