DegronMD - Q8WYK2(JDP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R145Q	TCGA-2W-A8YY	CESC	TCGA	VKTPESE	DEG_SCF_FBW7_2	146:152	Mutation blocking phosphorylation signal	0.75
p.R145Q	DO223732	CESC	ICGC	VKTPESE	DEG_SCF_FBW7_2	146:152	Mutation blocking phosphorylation signal	0.75
p.R147C	TCGA-33-6737	LUSC	TCGA	VKTPESE	DEG_SCF_FBW7_2	146:152	Mutation altering degron motif	0.8301
p.R147C	DO26866	LUSC	ICGC	VKTPESE	DEG_SCF_FBW7_2	146:152	Mutation altering degron motif	0.8301
p.R136L	TCGA-86-8673	LUAD	TCGA	VKTPESE	DEG_SCF_FBW7_2	146:152	Mutation rewiring degron network	0.0556
p.R136L	DO26260	LUAD	ICGC	VKTPESE	DEG_SCF_FBW7_2	146:152	Mutation rewiring degron network	0.0556
p.K158M	TCGA-AX-A063	UCEC	TCGA	VKTPESE	DEG_SCF_FBW7_2	146:152	Mutation rewiring degron network	0.1667
p.R147H	TCGA-CV-7440	HNSC	TCGA	VKTPESE	DEG_SCF_FBW7_2	146:152	Mutation altering degron motif	0.8244
p.R147H	DO15078	HNSC	ICGC	VKTPESE	DEG_SCF_FBW7_2	146:152	Mutation altering degron motif	0.8244
p.T149I	DO228955	LICA	ICGC	VKTPESE	DEG_SCF_FBW7_2	146:152	Mutation altering degron motif	0.7078
p.V141I	DO232224	PBCA	ICGC	VKTPESE	DEG_SCF_FBW7_2	146:152	Mutation rewiring degron network	0.1944
p.P160S	DO229459	SKCA	ICGC	VKTPESE	DEG_SCF_FBW7_2	146:152	Mutation rewiring degron network	0.1111
p.K147M	DO42201	UCEC	ICGC	VKTPESE	DEG_SCF_FBW7_2	146:152	Mutation altering degron motif	0.6951
p.T149S	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	VKTPESE	DEG_SCF_FBW7_2	146:152	Mutation altering degron motif	0.7116
p.R153Q	SIDM00580	Acute Myeloid Leukemia	GDSC	VKTPESE	DEG_SCF_FBW7_2	146:152	Mutation rewiring degron network	0.3056
p.R153Q	NOMO-1	haematopoietic and lymphoid tissue	COSMIC	VKTPESE	DEG_SCF_FBW7_2	146:152	Mutation rewiring degron network	0.3056
p.N144S	SIDM01608	Endometrial Carcinoma	GDSC	VKTPESE	DEG_SCF_FBW7_2	146:152	Mutation rewiring degron network	0.2778
p.R142Q	ACH-000168	Leukemia	CCLE	VKTPESE	DEG_SCF_FBW7_2	146:152	Mutation rewiring degron network	0.2222
p.R142Q	NOMO-1	haematopoietic and lymphoid tissue	COSMIC	VKTPESE	DEG_SCF_FBW7_2	146:152	Mutation rewiring degron network	0.2222
p.E158K	ACH-000970	Colon/Colorectal Cancer	CCLE	VKTPESE	DEG_SCF_FBW7_2	146:152	Mutation rewiring degron network	0.1667
p.E158K	SNU-C5	large intestine	COSMIC	VKTPESE	DEG_SCF_FBW7_2	146:152	Mutation rewiring degron network	0.1667

Kaplan plot for JDP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

JDP2

UniProt ID: Q8WYK2

Entrez ID: 122953

Protein name: Jun dimerization protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for JDP2 in