DegronMD

Uniprot ID: Q8WYK2

Source protein: Jun dimerization protein 2

Source gene: JDP2

Class: DEG_SCF_FBW7_2

Location: 146:152

E3 ligase: FBXW7

DEGRON score: 0.8156

ASA_SCORE: 97.9571

COIL: 0.8879

CONS_SCORE: 0.5253

DSS_SCORE: 0.5473

HELIX: 0.0854

FCONS_SCORE: 0.9146

RIG_SCORE: 0.6658

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R145Q	TCGA-2W-A8YY	CESC	TCGA	VKTPESE	DEG_SCF_FBW7_2	0.75
p.R145Q	DO223732	CESC	ICGC	VKTPESE	DEG_SCF_FBW7_2	0.75
p.R147C	TCGA-33-6737	LUSC	TCGA	VKTPESE	DEG_SCF_FBW7_2	0.8301
p.R147C	DO26866	LUSC	ICGC	VKTPESE	DEG_SCF_FBW7_2	0.8301
p.R136L	TCGA-86-8673	LUAD	TCGA	VKTPESE	DEG_SCF_FBW7_2	0.0556
p.R136L	DO26260	LUAD	ICGC	VKTPESE	DEG_SCF_FBW7_2	0.0556
p.K158M	TCGA-AX-A063	UCEC	TCGA	VKTPESE	DEG_SCF_FBW7_2	0.1667
p.R147H	TCGA-CV-7440	HNSC	TCGA	VKTPESE	DEG_SCF_FBW7_2	0.8244
p.R147H	DO15078	HNSC	ICGC	VKTPESE	DEG_SCF_FBW7_2	0.8244
p.T149I	DO228955	LICA	ICGC	VKTPESE	DEG_SCF_FBW7_2	0.7078
p.V141I	DO232224	PBCA	ICGC	VKTPESE	DEG_SCF_FBW7_2	0.1944
p.P160S	DO229459	SKCA	ICGC	VKTPESE	DEG_SCF_FBW7_2	0.1111
p.K147M	DO42201	UCEC	ICGC	VKTPESE	DEG_SCF_FBW7_2	0.6951
p.T149S	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	VKTPESE	DEG_SCF_FBW7_2	0.7116
p.R153Q	SIDM00580	Acute Myeloid Leukemia	GDSC	VKTPESE	DEG_SCF_FBW7_2	0.3056
p.R153Q	NOMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	VKTPESE	DEG_SCF_FBW7_2	0.3056
p.N144S	SIDM01608	Endometrial Carcinoma	GDSC	VKTPESE	DEG_SCF_FBW7_2	0.2778
p.R142Q	ACH-000168	Leukemia	CCLE	VKTPESE	DEG_SCF_FBW7_2	0.2222
p.R142Q	NOMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	VKTPESE	DEG_SCF_FBW7_2	0.2222
p.E158K	ACH-000970	Colon/Colorectal Cancer	CCLE	VKTPESE	DEG_SCF_FBW7_2	0.1667
p.E158K	SNU-C5	large_intestine	COSMIC	VKTPESE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WYK2	Jun dimerization protein 2	DEG_SCF_FBW7_2	146:152	VKTPESE	FBXW7	0.8156	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons