DegronMD - Q8WYR1(PIK3R5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L595M	TCGA-17-Z016	LUAD	TCGA	LGTTPWEE	DEG_SCF_FBW7_2	595:602	Mutation altering degron motif	0.5999
p.L595M	TCGA-DX-A6YT	SARC	TCGA	LGTTPWEE	DEG_SCF_FBW7_2	595:602	Mutation altering degron motif	0.5999
p.L595M	DO220007	SARC	ICGC	LGTTPWEE	DEG_SCF_FBW7_2	595:602	Mutation altering degron motif	0.5999
p.D585N	TCGA-19-5956	GBM	TCGA	LGTTPWEE	DEG_SCF_FBW7_2	595:602	Mutation rewiring degron network	0.0556
p.D585N	DO13863	GBM	ICGC	LGTTPWEE	DEG_SCF_FBW7_2	595:602	Mutation rewiring degron network	0.0556
p.Y610N	TCGA-69-7973	LUAD	TCGA	LGTTPWEE	DEG_SCF_FBW7_2	595:602	Mutation rewiring degron network	0.1111
p.Y610N	DO23870	LUAD	ICGC	LGTTPWEE	DEG_SCF_FBW7_2	595:602	Mutation rewiring degron network	0.1111
p.W600L	TCGA-D3-A2JD	SKCM	TCGA	LGTTPWEE	DEG_SCF_FBW7_2	595:602	Mutation altering degron motif	0.5904
p.W600L	DO37543	SKCM	ICGC	LGTTPWEE	DEG_SCF_FBW7_2	595:602	Mutation altering degron motif	0.5904
p.N605D	TCGA-EO-A3KX	UCEC	TCGA	LGTTPWEE	DEG_SCF_FBW7_2	595:602	Mutation rewiring degron network	0.25
p.N605D	DO219774	UCEC	ICGC	LGTTPWEE	DEG_SCF_FBW7_2	595:602	Mutation rewiring degron network	0.25
p.W600C	TCGA-ER-A19P	SKCM	TCGA	LGTTPWEE	DEG_SCF_FBW7_2	595:602	Mutation altering degron motif	0.5889
p.W600C	DO47623	SKCM	ICGC	LGTTPWEE	DEG_SCF_FBW7_2	595:602	Mutation altering degron motif	0.5889
p.P599S	DO222402	MELA	ICGC	LGTTPWEE	DEG_SCF_FBW7_2	595:602	Mutation altering degron motif	0.6752
p.P599S	DO229453	SKCA	ICGC	LGTTPWEE	DEG_SCF_FBW7_2	595:602	Mutation altering degron motif	0.6752
p.H589Y	DO232224	PBCA	ICGC	LGTTPWEE	DEG_SCF_FBW7_2	595:602	Mutation rewiring degron network	0.1667
p.A590T	DO36253	PRAD	ICGC	LGTTPWEE	DEG_SCF_FBW7_2	595:602	Mutation rewiring degron network	0.1944
p.G612S	SIDM01293	Colorectal Carcinoma	GDSC	LGTTPWEE	DEG_SCF_FBW7_2	595:602	Mutation rewiring degron network	0.0556
p.P592S	SIDM00140	Melanoma	GDSC	LGTTPWEE	DEG_SCF_FBW7_2	595:602	Mutation rewiring degron network	0.25
p.P592S	ACH-000968	Skin Cancer	CCLE	LGTTPWEE	DEG_SCF_FBW7_2	595:602	Mutation rewiring degron network	0.25
p.P592S	COLO-792	skin	COSMIC	LGTTPWEE	DEG_SCF_FBW7_2	595:602	Mutation rewiring degron network	0.25

Kaplan plot for PIK3R5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PIK3R5

UniProt ID: Q8WYR1

Entrez ID: 23533

Protein name: Phosphoinositide 3-kinase regulatory subunit 5 (PI3-kinase regulatory subunit 5) (PI3-kinase p101 subunit) (Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit) (PtdIns-3-kinase regulatory subunit) (Protein FOAP-2) (PtdIns-3-kinase p101) (p101-PI3K)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PIK3R5 in