DegronMD

Uniprot ID: Q8WYR1

Source protein: Phosphoinositide 3-kinase regulatory subunit 5

Source gene: PIK3R5

Class: DEG_SCF_FBW7_2

Location: 595:602

E3 ligase: FBXW7

DEGRON score: 0.9034

ASA_SCORE: 75.7625

COIL: 0.8116

CONS_SCORE: 0.4664

DSS_SCORE: 0.6384

HELIX: 0.1169

FCONS_SCORE: 0.7025

RIG_SCORE: 0.6462

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L595M	TCGA-17-Z016	LUAD	TCGA	LGTTPWEE	DEG_SCF_FBW7_2	0.5999
p.L595M	TCGA-DX-A6YT	SARC	TCGA	LGTTPWEE	DEG_SCF_FBW7_2	0.5999
p.L595M	DO220007	SARC	ICGC	LGTTPWEE	DEG_SCF_FBW7_2	0.5999
p.D585N	TCGA-19-5956	GBM	TCGA	LGTTPWEE	DEG_SCF_FBW7_2	0.0556
p.D585N	DO13863	GBM	ICGC	LGTTPWEE	DEG_SCF_FBW7_2	0.0556
p.Y610N	TCGA-69-7973	LUAD	TCGA	LGTTPWEE	DEG_SCF_FBW7_2	0.1111
p.Y610N	DO23870	LUAD	ICGC	LGTTPWEE	DEG_SCF_FBW7_2	0.1111
p.W600L	TCGA-D3-A2JD	SKCM	TCGA	LGTTPWEE	DEG_SCF_FBW7_2	0.5904
p.W600L	DO37543	SKCM	ICGC	LGTTPWEE	DEG_SCF_FBW7_2	0.5904
p.N605D	TCGA-EO-A3KX	UCEC	TCGA	LGTTPWEE	DEG_SCF_FBW7_2	0.25
p.N605D	DO219774	UCEC	ICGC	LGTTPWEE	DEG_SCF_FBW7_2	0.25
p.W600C	TCGA-ER-A19P	SKCM	TCGA	LGTTPWEE	DEG_SCF_FBW7_2	0.5889
p.W600C	DO47623	SKCM	ICGC	LGTTPWEE	DEG_SCF_FBW7_2	0.5889
p.P599S	DO222402	MELA	ICGC	LGTTPWEE	DEG_SCF_FBW7_2	0.6752
p.P599S	DO229453	SKCA	ICGC	LGTTPWEE	DEG_SCF_FBW7_2	0.6752
p.H589Y	DO232224	PBCA	ICGC	LGTTPWEE	DEG_SCF_FBW7_2	0.1667
p.A590T	DO36253	PRAD	ICGC	LGTTPWEE	DEG_SCF_FBW7_2	0.1944
p.G612S	SIDM01293	Colorectal Carcinoma	GDSC	LGTTPWEE	DEG_SCF_FBW7_2	0.0556
p.P592S	SIDM00140	Melanoma	GDSC	LGTTPWEE	DEG_SCF_FBW7_2	0.25
p.P592S	ACH-000968	Skin Cancer	CCLE	LGTTPWEE	DEG_SCF_FBW7_2	0.25
p.P592S	COLO-792	skin	COSMIC	LGTTPWEE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WYR1	Phosphoinositide 3-kinase regulatory subunit 5	DEG_SCF_FBW7_2	595:602	LGTTPWEE	FBXW7	0.9034	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons