DegronMD - Q8WZA9(IRGQ)

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G53D	TCGA-EK-A2PM	CESC	TCGA	DSGVPS	DEG_SCF_TRCP1_1	43:48	Mutation rewiring degron network	0.1944
p.G53D	DO49941	CESC	ICGC	DSGVPS	DEG_SCF_TRCP1_1	43:48	Mutation rewiring degron network	0.1944
p.E39K	TCGA-Q1-A73O	CESC	TCGA	DSGVPS	DEG_SCF_TRCP1_1	43:48	Mutation rewiring degron network	0.2222
p.E39K	DO51612	CESC	ICGC	DSGVPS	DEG_SCF_TRCP1_1	43:48	Mutation rewiring degron network	0.2222
p.L35R	DO222626	BTCA	ICGC	DSGVPS	DEG_SCF_TRCP1_1	43:48	Mutation rewiring degron network	0.1111
p.S48T	DO233672	GACA	ICGC	DSGVPS	DEG_SCF_TRCP1_1	43:48	Mutation altering degron motif	0.6005
p.A51V	DO229079	PRAD	ICGC	DSGVPS	DEG_SCF_TRCP1_1	43:48	Mutation rewiring degron network	0.25
p.P42L	SIDM01554	Mesothelioma	GDSC	DSGVPS	DEG_SCF_TRCP1_1	43:48	Mutation rewiring degron network	0.3056
p.P42L	ACH-000331	Lung Cancer	CCLE	DSGVPS	DEG_SCF_TRCP1_1	43:48	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons