DegronMD

Uniprot ID: Q8WZA9

Source protein: Immunity-related GTPase family Q protein

Source gene: IRGQ

Class: DEG_SCF_TRCP1_1

Location: 43:48

E3 ligase: BTRC

DEGRON score: 0.9788

ASA_SCORE: 66.3667

COIL: 0.8225

CONS_SCORE: 0.9244

DSS_SCORE: 0.5523

HELIX: 0.0235

FCONS_SCORE: 1.0467

RIG_SCORE: 0.6591

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G53D	TCGA-EK-A2PM	CESC	TCGA	DSGVPS	DEG_SCF_TRCP1_1	0.1944
p.G53D	DO49941	CESC	ICGC	DSGVPS	DEG_SCF_TRCP1_1	0.1944
p.E39K	TCGA-Q1-A73O	CESC	TCGA	DSGVPS	DEG_SCF_TRCP1_1	0.2222
p.E39K	DO51612	CESC	ICGC	DSGVPS	DEG_SCF_TRCP1_1	0.2222
p.L35R	DO222626	BTCA	ICGC	DSGVPS	DEG_SCF_TRCP1_1	0.1111
p.S48T	DO233672	GACA	ICGC	DSGVPS	DEG_SCF_TRCP1_1	0.6005
p.A51V	DO229079	PRAD	ICGC	DSGVPS	DEG_SCF_TRCP1_1	0.25
p.P42L	SIDM01554	Mesothelioma	GDSC	DSGVPS	DEG_SCF_TRCP1_1	0.3056
p.P42L	ACH-000331	Lung Cancer	CCLE	DSGVPS	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZA9	Immunity-related GTPase family Q protein	DEG_SCF_TRCP1_1	43:48	DSGVPS	BTRC	0.9788	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons