DegronMD - Q92485(SMPDL3B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A56T	TCGA-A5-A2K5	UCEC	TCGA	SAGSQPVPDA	DEG_COP1_1	47:56	Mutation altering degron motif	0.7139
p.A56T	DO41379	UCEC	ICGC	SAGSQPVPDA	DEG_COP1_1	47:56	Mutation altering degron motif	0.7139
p.A56T	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	SAGSQPVPDA	DEG_COP1_1	47:56	Mutation altering degron motif	0.7139
p.A56T	ACH-000916	Lung Cancer	CCLE	SAGSQPVPDA	DEG_COP1_1	47:56	Mutation altering degron motif	0.7139
p.A56T	NCI-H1573	lung	COSMIC	SAGSQPVPDA	DEG_COP1_1	47:56	Mutation altering degron motif	0.7139
p.F42L	TCGA-BR-8078	STAD	TCGA	SAGSQPVPDA	DEG_COP1_1	47:56	Mutation rewiring degron network	0.1944
p.F42L	DO38288	STAD	ICGC	SAGSQPVPDA	DEG_COP1_1	47:56	Mutation rewiring degron network	0.1944
p.S50F	TCGA-D3-A3C7	SKCM	TCGA	SAGSQPVPDA	DEG_COP1_1	47:56	Mutation altering degron motif	0.7982
p.S50F	TCGA-VS-A958	CESC	TCGA	SAGSQPVPDA	DEG_COP1_1	47:56	Mutation altering degron motif	0.7982
p.S50F	DO51639	CESC	ICGC	SAGSQPVPDA	DEG_COP1_1	47:56	Mutation altering degron motif	0.7982
p.S50F	DO47569	SKCM	ICGC	SAGSQPVPDA	DEG_COP1_1	47:56	Mutation altering degron motif	0.7982
p.V44M	TCGA-D3-A8GO	SKCM	TCGA	SAGSQPVPDA	DEG_COP1_1	47:56	Mutation rewiring degron network	0.25
p.V44M	DO51242	SKCM	ICGC	SAGSQPVPDA	DEG_COP1_1	47:56	Mutation rewiring degron network	0.25
p.G57C	TCGA-DF-A2KN	UCEC	TCGA	SAGSQPVPDA	DEG_COP1_1	47:56	Mutation rewiring degron network	0.3056
p.G57C	DO223282	UCEC	ICGC	SAGSQPVPDA	DEG_COP1_1	47:56	Mutation rewiring degron network	0.3056
p.P58S	TCGA-EE-A2MJ	SKCM	TCGA	SAGSQPVPDA	DEG_COP1_1	47:56	Mutation rewiring degron network	0.2778
p.P58S	DO38099	SKCM	ICGC	SAGSQPVPDA	DEG_COP1_1	47:56	Mutation rewiring degron network	0.2778
p.G49E	TCGA-GN-A8LK	SKCM	TCGA	SAGSQPVPDA	DEG_COP1_1	47:56	Mutation altering degron motif	0.6087
p.G49E	DO51259	SKCM	ICGC	SAGSQPVPDA	DEG_COP1_1	47:56	Mutation altering degron motif	0.6087
p.L63P	TCGA-ZF-A9RC	BLCA	TCGA	SAGSQPVPDA	DEG_COP1_1	47:56	Mutation rewiring degron network	0.1389
p.L63P	DO219068	BLCA	ICGC	SAGSQPVPDA	DEG_COP1_1	47:56	Mutation rewiring degron network	0.1389
p.V37I	DO233764	GACA	ICGC	SAGSQPVPDA	DEG_COP1_1	47:56	Mutation rewiring degron network	0.0556

Kaplan plot for SMPDL3B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMPDL3B

UniProt ID: Q92485

Entrez ID: 27293

Protein name: Acid sphingomyelinase-like phosphodiesterase 3b (ASM-like phosphodiesterase 3b) (EC 3.1.4.-)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SMPDL3B in