DegronMD

Uniprot ID: Q92485

Source protein: Acid sphingomyelinase-like phosphodiesterase 3b

Source gene: SMPDL3B

Class: DEG_COP1_1

Location: 47:56

E3 ligase: COP1

DEGRON score: 0.8571

ASA_SCORE: 79.8

COIL: 0.9246

CONS_SCORE: 0.3046

DSS_SCORE: 0.4463

HELIX: 0.0248

FCONS_SCORE: 0.6298

RIG_SCORE: 0.6619

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S50F	TCGA-D3-A3C7	SKCM	TCGA	SAGSQPVPDA	DEG_COP1_1	0.7982
p.S50F	TCGA-VS-A958	CESC	TCGA	SAGSQPVPDA	DEG_COP1_1	0.7982
p.S50F	DO51639	CESC	ICGC	SAGSQPVPDA	DEG_COP1_1	0.7982
p.S50F	DO47569	SKCM	ICGC	SAGSQPVPDA	DEG_COP1_1	0.7982
p.A56T	TCGA-A5-A2K5	UCEC	TCGA	SAGSQPVPDA	DEG_COP1_1	0.7139
p.A56T	DO41379	UCEC	ICGC	SAGSQPVPDA	DEG_COP1_1	0.7139
p.A56T	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	SAGSQPVPDA	DEG_COP1_1	0.7139
p.A56T	ACH-000916	Lung Cancer	CCLE	SAGSQPVPDA	DEG_COP1_1	0.7139
p.A56T	NCI-H1573	lung	COSMIC	SAGSQPVPDA	DEG_COP1_1	0.7139
p.G49E	TCGA-GN-A8LK	SKCM	TCGA	SAGSQPVPDA	DEG_COP1_1	0.6087
p.G49E	DO51259	SKCM	ICGC	SAGSQPVPDA	DEG_COP1_1	0.6087
p.G57C	TCGA-DF-A2KN	UCEC	TCGA	SAGSQPVPDA	DEG_COP1_1	0.3056
p.G57C	DO223282	UCEC	ICGC	SAGSQPVPDA	DEG_COP1_1	0.3056
p.P58S	TCGA-EE-A2MJ	SKCM	TCGA	SAGSQPVPDA	DEG_COP1_1	0.2778
p.P58S	DO38099	SKCM	ICGC	SAGSQPVPDA	DEG_COP1_1	0.2778
p.V44M	TCGA-D3-A8GO	SKCM	TCGA	SAGSQPVPDA	DEG_COP1_1	0.25
p.V44M	DO51242	SKCM	ICGC	SAGSQPVPDA	DEG_COP1_1	0.25
p.F42L	TCGA-BR-8078	STAD	TCGA	SAGSQPVPDA	DEG_COP1_1	0.1944
p.F42L	DO38288	STAD	ICGC	SAGSQPVPDA	DEG_COP1_1	0.1944
p.L63P	TCGA-ZF-A9RC	BLCA	TCGA	SAGSQPVPDA	DEG_COP1_1	0.1389
p.L63P	DO219068	BLCA	ICGC	SAGSQPVPDA	DEG_COP1_1	0.1389
p.V37I	DO233764	GACA	ICGC	SAGSQPVPDA	DEG_COP1_1	0.0556

Showing 1 to 22 of 22 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92485	Acid sphingomyelinase-like phosphodiesterase 3b	DEG_COP1_1	47:56	SAGSQPVPDA	COP1	0.8571	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons