DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
SAGSQPVPDA
Uniprot ID:
Q92485
Source protein:
Acid sphingomyelinase-like phosphodiesterase 3b
Source gene:
SMPDL3B
Class:
DEG_COP1_1
Location:
47:56
E3 ligase:
COP1
DEGRON score:
0.8571
ASA_SCORE:
79.8
COIL:
0.9246
CONS_SCORE:
0.3046
DSS_SCORE:
0.4463
HELIX:
0.0248
FCONS_SCORE:
0.6298
RIG_SCORE:
0.6619
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A56T
TCGA-A5-A2K5
UCEC
TCGA
SAGSQPVPDA
DEG_COP1_1
0.7139
p.A56T
DO41379
UCEC
ICGC
SAGSQPVPDA
DEG_COP1_1
0.7139
p.A56T
SIDM00749
Non-Small Cell Lung Carcinoma
GDSC
SAGSQPVPDA
DEG_COP1_1
0.7139
p.A56T
ACH-000916
Lung Cancer
CCLE
SAGSQPVPDA
DEG_COP1_1
0.7139
p.A56T
NCI-H1573
lung
COSMIC
SAGSQPVPDA
DEG_COP1_1
0.7139
p.F42L
TCGA-BR-8078
STAD
TCGA
SAGSQPVPDA
DEG_COP1_1
0.1944
p.F42L
DO38288
STAD
ICGC
SAGSQPVPDA
DEG_COP1_1
0.1944
p.S50F
TCGA-D3-A3C7
SKCM
TCGA
SAGSQPVPDA
DEG_COP1_1
0.7982
p.S50F
TCGA-VS-A958
CESC
TCGA
SAGSQPVPDA
DEG_COP1_1
0.7982
p.S50F
DO51639
CESC
ICGC
SAGSQPVPDA
DEG_COP1_1
0.7982
p.S50F
DO47569
SKCM
ICGC
SAGSQPVPDA
DEG_COP1_1
0.7982
p.V44M
TCGA-D3-A8GO
SKCM
TCGA
SAGSQPVPDA
DEG_COP1_1
0.25
p.V44M
DO51242
SKCM
ICGC
SAGSQPVPDA
DEG_COP1_1
0.25
p.G57C
TCGA-DF-A2KN
UCEC
TCGA
SAGSQPVPDA
DEG_COP1_1
0.3056
p.G57C
DO223282
UCEC
ICGC
SAGSQPVPDA
DEG_COP1_1
0.3056
p.P58S
TCGA-EE-A2MJ
SKCM
TCGA
SAGSQPVPDA
DEG_COP1_1
0.2778
p.P58S
DO38099
SKCM
ICGC
SAGSQPVPDA
DEG_COP1_1
0.2778
p.G49E
TCGA-GN-A8LK
SKCM
TCGA
SAGSQPVPDA
DEG_COP1_1
0.6087
p.G49E
DO51259
SKCM
ICGC
SAGSQPVPDA
DEG_COP1_1
0.6087
p.L63P
TCGA-ZF-A9RC
BLCA
TCGA
SAGSQPVPDA
DEG_COP1_1
0.1389
p.L63P
DO219068
BLCA
ICGC
SAGSQPVPDA
DEG_COP1_1
0.1389
p.V37I
DO233764
GACA
ICGC
SAGSQPVPDA
DEG_COP1_1
0.0556
Drug responses associated with SMPDL3B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SAGSQPVPDA
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q92485
Acid sphingomyelinase-like phosphodiesterase 3b
DEG_COP1_1
47:56
SAGSQPVPDA
COP1
0.8571
More...