DegronMD - Q92519(TRIB2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G320D	TCGA-23-1027	OV	TCGA	EVSDQLVPDV	DEG_COP1_1	323:332	Mutation rewiring degron network	0.25
p.M334K	TCGA-44-2656	LUAD	TCGA	EVSDQLVPDV	DEG_COP1_1	323:332	Mutation rewiring degron network	0.2778
p.M334I	TCGA-44-2656	LUAD	TCGA	EVSDQLVPDV	DEG_COP1_1	323:332	Mutation rewiring degron network	0.2778
p.S313C	TCGA-78-7155	LUAD	TCGA	EVSDQLVPDV	DEG_COP1_1	323:332	Mutation rewiring degron network	0.0556
p.V314I	TCGA-A6-5661	COAD	TCGA	EVSDQLVPDV	DEG_COP1_1	323:332	Mutation rewiring degron network	0.0833
p.V314I	TCGA-AZ-6607	COAD	TCGA	EVSDQLVPDV	DEG_COP1_1	323:332	Mutation rewiring degron network	0.0833
p.E336D	TCGA-AA-3984	COAD	TCGA	EVSDQLVPDV	DEG_COP1_1	323:332	Mutation rewiring degron network	0.2222
p.E336D	TCGA-EO-A3B0	UCEC	TCGA	EVSDQLVPDV	DEG_COP1_1	323:332	Mutation rewiring degron network	0.2222
p.E336D	SIDM00193	Colorectal Carcinoma	GDSC	EVSDQLVPDV	DEG_COP1_1	323:332	Mutation rewiring degron network	0.2222
p.E336D	ACH-000991	Colon/Colorectal Cancer	CCLE	EVSDQLVPDV	DEG_COP1_1	323:332	Mutation rewiring degron network	0.2222
p.E336D	SNU-81	large intestine	COSMIC	EVSDQLVPDV	DEG_COP1_1	323:332	Mutation rewiring degron network	0.2222
p.A318T	TCGA-AG-3892	READ	TCGA	EVSDQLVPDV	DEG_COP1_1	323:332	Mutation rewiring degron network	0.1944
p.D331G	TCGA-AX-A06F	UCEC	TCGA	EVSDQLVPDV	DEG_COP1_1	323:332	Mutation altering degron motif	0.7198
p.S317L	TCGA-BH-A0HF	BRCA	TCGA	EVSDQLVPDV	DEG_COP1_1	323:332	Mutation rewiring degron network	0.1667
p.V324M	TCGA-HB-A43Z	SARC	TCGA	EVSDQLVPDV	DEG_COP1_1	323:332	Mutation altering degron motif	0.6097
p.D331V	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	EVSDQLVPDV	DEG_COP1_1	323:332	Mutation altering degron motif	0.7785
p.D331V	ACH-000733	Lung Cancer	CCLE	EVSDQLVPDV	DEG_COP1_1	323:332	Mutation altering degron motif	0.7785
p.D331V	NCI-H1838	lung	COSMIC	EVSDQLVPDV	DEG_COP1_1	323:332	Mutation altering degron motif	0.7785

Kaplan plot for TRIB2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRIB2

UniProt ID: Q92519

Entrez ID: 28951

Protein name: Tribbles homolog 2 (TRB-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRIB2 in