DegronMD

Uniprot ID: Q92519

Source protein: Tribbles homolog 2

Source gene: TRIB2

Class: DEG_COP1_1

Location: 323:332

E3 ligase: COP1

DEGRON score: 0.9955

ASA_SCORE: 73.81

COIL: 0.7406

CONS_SCORE: 0.7135

DSS_SCORE: 0.4371

HELIX: 0.1732

FCONS_SCORE: 1.5171

RIG_SCORE: 0.7871

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G320D	TCGA-23-1027	OV	TCGA	EVSDQLVPDV	DEG_COP1_1	0.25
p.M334K	TCGA-44-2656	LUAD	TCGA	EVSDQLVPDV	DEG_COP1_1	0.2778
p.M334I	TCGA-44-2656	LUAD	TCGA	EVSDQLVPDV	DEG_COP1_1	0.2778
p.S313C	TCGA-78-7155	LUAD	TCGA	EVSDQLVPDV	DEG_COP1_1	0.0556
p.V314I	TCGA-A6-5661	COAD	TCGA	EVSDQLVPDV	DEG_COP1_1	0.0833
p.V314I	TCGA-AZ-6607	COAD	TCGA	EVSDQLVPDV	DEG_COP1_1	0.0833
p.E336D	TCGA-AA-3984	COAD	TCGA	EVSDQLVPDV	DEG_COP1_1	0.2222
p.E336D	TCGA-EO-A3B0	UCEC	TCGA	EVSDQLVPDV	DEG_COP1_1	0.2222
p.E336D	SIDM00193	Colorectal Carcinoma	GDSC	EVSDQLVPDV	DEG_COP1_1	0.2222
p.E336D	ACH-000991	Colon/Colorectal Cancer	CCLE	EVSDQLVPDV	DEG_COP1_1	0.2222
p.E336D	SNU-81	large_intestine	COSMIC	EVSDQLVPDV	DEG_COP1_1	0.2222
p.A318T	TCGA-AG-3892	READ	TCGA	EVSDQLVPDV	DEG_COP1_1	0.1944
p.D331G	TCGA-AX-A06F	UCEC	TCGA	EVSDQLVPDV	DEG_COP1_1	0.7198
p.S317L	TCGA-BH-A0HF	BRCA	TCGA	EVSDQLVPDV	DEG_COP1_1	0.1667
p.V324M	TCGA-HB-A43Z	SARC	TCGA	EVSDQLVPDV	DEG_COP1_1	0.6097
p.D331V	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	EVSDQLVPDV	DEG_COP1_1	0.7785
p.D331V	ACH-000733	Lung Cancer	CCLE	EVSDQLVPDV	DEG_COP1_1	0.7785
p.D331V	NCI-H1838	lung	COSMIC	EVSDQLVPDV	DEG_COP1_1	0.7785

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92519	Tribbles homolog 2	DEG_COP1_1	323:332	EVSDQLVPDV	COP1	0.9955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons