DegronMD - Q92565(RAPGEF5)

FUNCTION: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation. {ECO:0000269|PubMed:10777494, ECO:0000269|PubMed:10934204}.

GO - Biological processes (BP): nervous system development [GO:0007399]; positive regulation of GTPase activity [GO:0043547]; Ras protein signal transduction [GO:0007265]; small GTPase mediated signal transduction [GO:0007264]

GO - Molecular function (MF): GTP-dependent protein binding [GO:0030742]; guanyl-nucleotide exchange factor activity [GO:0005085]

GO - Cellular component (CC): nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S330F	DO24307	LUAD	ICGC	LNPFAE	LIG_APCC_ABBA_1	325:330	Mutation altering degron motif	0.7982
p.K325I	DO51247	SKCM	ICGC	LNPFAE	LIG_APCC_ABBA_1	325:330	Mutation altering degron motif	0.7531
p.F328L	ACH-000994	Endometrial/Uterine Cancer	CCLE	LNPFAE	LIG_APCC_ABBA_1	325:330	Mutation altering degron motif	0.6981
p.D331Y	TCGA-A5-A0G1	UCEC	TCGA	LNPFAE	LIG_APCC_ABBA_1	325:330	Mutation rewiring degron network	0.3056
p.T324I	TCGA-B5-A3FA	UCEC	TCGA	LNPFAE	LIG_APCC_ABBA_1	325:330	Mutation rewiring degron network	0.3056
p.E331G	DO50936	LICA	ICGC	LNPFAE	LIG_APCC_ABBA_1	325:330	Mutation rewiring degron network	0.3056
p.K319N	TCGA-AX-A06F	UCEC	TCGA	LNPFAE	LIG_APCC_ABBA_1	325:330	Mutation substituting flanking lysine	0.2778
p.F319V	DO9474	COAD	ICGC	LNPFAE	LIG_APCC_ABBA_1	325:330	Mutation substituting flanking lysine	0.2778
p.D323E	DO229032	LICA	ICGC	LNPFAE	LIG_APCC_ABBA_1	325:330	Mutation rewiring degron network	0.2778
p.D323N	DO37871	SKCM	ICGC	LNPFAE	LIG_APCC_ABBA_1	325:330	Mutation rewiring degron network	0.2778
p.D323N	ACH-000582	Skin Cancer	CCLE	LNPFAE	LIG_APCC_ABBA_1	325:330	Mutation rewiring degron network	0.2778
p.D323N	COLO-741	large intestine	COSMIC	LNPFAE	LIG_APCC_ABBA_1	325:330	Mutation rewiring degron network	0.2778
p.D323Y	ACH-002193	Lung Cancer	CCLE	LNPFAE	LIG_APCC_ABBA_1	325:330	Mutation rewiring degron network	0.2778
p.D323Y	RERF-LC-FM	lung	COSMIC	LNPFAE	LIG_APCC_ABBA_1	325:330	Mutation rewiring degron network	0.2778
p.T322M	DO10510	COAD	ICGC	LNPFAE	LIG_APCC_ABBA_1	325:330	Mutation rewiring degron network	0.25
p.A322E	DO229031	LICA	ICGC	LNPFAE	LIG_APCC_ABBA_1	325:330	Mutation rewiring degron network	0.25
p.E333K	DO222572	MELA	ICGC	LNPFAE	LIG_APCC_ABBA_1	325:330	Mutation rewiring degron network	0.25
p.A322V	DO46657	PAAD	ICGC	LNPFAE	LIG_APCC_ABBA_1	325:330	Mutation rewiring degron network	0.25
p.Q321L	DO223915	LIHC	ICGC	LNPFAE	LIG_APCC_ABBA_1	325:330	Mutation rewiring degron network	0.2222
p.Q321H	ACH-000791	Lung Cancer	CCLE	LNPFAE	LIG_APCC_ABBA_1	325:330	Mutation rewiring degron network	0.2222

Showing 1 to 20 of 34 entries

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No resistance data available for this Degron.

Kaplan plot for RAPGEF5 in

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

RAPGEF5

UniProt ID: Q92565

Entrez ID: 9771

Protein name: Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF) (Related to Epac) (Repac)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for RAPGEF5 in