DegronMD

Uniprot ID: Q92565

Source protein: Rap guanine nucleotide exchange factor 5

Source gene: RAPGEF5

Class: LIG_APCC_ABBA_1

Location: 325:330

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.907

ASA_SCORE: 79.9833

COIL: 0.6538

CONS_SCORE: 0.5069

DSS_SCORE: 0.4338

HELIX: 0.2877

FCONS_SCORE: 1.2903

RIG_SCORE: 0.7844

Show entries

Search:

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S330F	DO24307	LUAD	ICGC	LNPFAE	LIG_APCC_ABBA_1	0.7982
p.K325I	DO51247	SKCM	ICGC	LNPFAE	LIG_APCC_ABBA_1	0.7531
p.F328L	ACH-000994	Endometrial/Uterine Cancer	CCLE	LNPFAE	LIG_APCC_ABBA_1	0.6981
p.D331Y	TCGA-A5-A0G1	UCEC	TCGA	LNPFAE	LIG_APCC_ABBA_1	0.3056
p.T324I	TCGA-B5-A3FA	UCEC	TCGA	LNPFAE	LIG_APCC_ABBA_1	0.3056
p.E331G	DO50936	LICA	ICGC	LNPFAE	LIG_APCC_ABBA_1	0.3056
p.K319N	TCGA-AX-A06F	UCEC	TCGA	LNPFAE	LIG_APCC_ABBA_1	0.2778
p.F319V	DO9474	COAD	ICGC	LNPFAE	LIG_APCC_ABBA_1	0.2778
p.D323E	DO229032	LICA	ICGC	LNPFAE	LIG_APCC_ABBA_1	0.2778
p.D323N	DO37871	SKCM	ICGC	LNPFAE	LIG_APCC_ABBA_1	0.2778
p.D323N	ACH-000582	Skin Cancer	CCLE	LNPFAE	LIG_APCC_ABBA_1	0.2778
p.D323N	COLO-741	large_intestine	COSMIC	LNPFAE	LIG_APCC_ABBA_1	0.2778
p.D323Y	ACH-002193	Lung Cancer	CCLE	LNPFAE	LIG_APCC_ABBA_1	0.2778
p.D323Y	RERF-LC-FM	lung	COSMIC	LNPFAE	LIG_APCC_ABBA_1	0.2778
p.T322M	DO10510	COAD	ICGC	LNPFAE	LIG_APCC_ABBA_1	0.25
p.A322E	DO229031	LICA	ICGC	LNPFAE	LIG_APCC_ABBA_1	0.25
p.E333K	DO222572	MELA	ICGC	LNPFAE	LIG_APCC_ABBA_1	0.25
p.A322V	DO46657	PAAD	ICGC	LNPFAE	LIG_APCC_ABBA_1	0.25
p.Q321L	DO223915	LIHC	ICGC	LNPFAE	LIG_APCC_ABBA_1	0.2222
p.Q321H	ACH-000791	Lung Cancer	CCLE	LNPFAE	LIG_APCC_ABBA_1	0.2222
p.D334N	ACH-001331	Head and Neck Cancer	CCLE	LNPFAE	LIG_APCC_ABBA_1	0.2222
p.D334N	BICR10	upper_aerodigestive_tract	COSMIC	LNPFAE	LIG_APCC_ABBA_1	0.2222
p.L320F	DO23666	LUAD	ICGC	LNPFAE	LIG_APCC_ABBA_1	0.1944
p.D320N	DO47584	SKCM	ICGC	LNPFAE	LIG_APCC_ABBA_1	0.1944
p.D320H	ACH-001459	Colon/Colorectal Cancer	CCLE	LNPFAE	LIG_APCC_ABBA_1	0.1944

Showing 1 to 25 of 34 entries

Show entries

Search:

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

Showing 0 to 0 of 0 entries

Show entries

Search:

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92565	Rap guanine nucleotide exchange factor 5	LIG_APCC_ABBA_1	325:330	LNPFAE	APC,CDC20,FZR1	0.907	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons