DegronMD

Uniprot ID: Q92565

Source protein: Rap guanine nucleotide exchange factor 5

Source gene: RAPGEF5

Class: LIG_APCC_ABBA_1

Location: 325:330

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.907

ASA_SCORE: 79.9833

COIL: 0.6538

CONS_SCORE: 0.5069

DSS_SCORE: 0.4338

HELIX: 0.2877

FCONS_SCORE: 1.2903

RIG_SCORE: 0.7844

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I338T	TCGA-2Z-A9JP	KIRP	TCGA	LNPFAE	LIG_APCC_ABBA_1	0.1111
p.D331Y	TCGA-A5-A0G1	UCEC	TCGA	LNPFAE	LIG_APCC_ABBA_1	0.3056
p.K319N	TCGA-AX-A06F	UCEC	TCGA	LNPFAE	LIG_APCC_ABBA_1	0.2778
p.T324I	TCGA-B5-A3FA	UCEC	TCGA	LNPFAE	LIG_APCC_ABBA_1	0.3056
p.T338M	DO222947	BTCA	ICGC	LNPFAE	LIG_APCC_ABBA_1	0.1111
p.T338M	DO29860	OV	ICGC	LNPFAE	LIG_APCC_ABBA_1	0.1111
p.F319V	DO9474	COAD	ICGC	LNPFAE	LIG_APCC_ABBA_1	0.2778
p.T322M	DO10510	COAD	ICGC	LNPFAE	LIG_APCC_ABBA_1	0.25
p.D323E	DO229032	LICA	ICGC	LNPFAE	LIG_APCC_ABBA_1	0.2778
p.A322E	DO229031	LICA	ICGC	LNPFAE	LIG_APCC_ABBA_1	0.25
p.E331G	DO50936	LICA	ICGC	LNPFAE	LIG_APCC_ABBA_1	0.3056
p.Q321L	DO223915	LIHC	ICGC	LNPFAE	LIG_APCC_ABBA_1	0.2222
p.S330F	DO24307	LUAD	ICGC	LNPFAE	LIG_APCC_ABBA_1	0.7982
p.L320F	DO23666	LUAD	ICGC	LNPFAE	LIG_APCC_ABBA_1	0.1944
p.E333K	DO222572	MELA	ICGC	LNPFAE	LIG_APCC_ABBA_1	0.25
p.A322V	DO46657	PAAD	ICGC	LNPFAE	LIG_APCC_ABBA_1	0.25
p.D323N	DO37871	SKCM	ICGC	LNPFAE	LIG_APCC_ABBA_1	0.2778
p.D323N	ACH-000582	Skin Cancer	CCLE	LNPFAE	LIG_APCC_ABBA_1	0.2778
p.D323N	COLO-741	large_intestine	COSMIC	LNPFAE	LIG_APCC_ABBA_1	0.2778
p.D320N	DO47584	SKCM	ICGC	LNPFAE	LIG_APCC_ABBA_1	0.1944
p.K325I	DO51247	SKCM	ICGC	LNPFAE	LIG_APCC_ABBA_1	0.7531
p.Q321H	ACH-000791	Lung Cancer	CCLE	LNPFAE	LIG_APCC_ABBA_1	0.2222
p.E315K	ACH-000991	Colon/Colorectal Cancer	CCLE	LNPFAE	LIG_APCC_ABBA_1	0.0556
p.E315K	ACH-001568	Skin Cancer	CCLE	LNPFAE	LIG_APCC_ABBA_1	0.0556
p.E315K	SNU-81	large_intestine	COSMIC	LNPFAE	LIG_APCC_ABBA_1	0.0556
p.F328L	ACH-000994	Endometrial/Uterine Cancer	CCLE	LNPFAE	LIG_APCC_ABBA_1	0.6981
p.Q318P	ACH-001081	Colon/Colorectal Cancer	CCLE	LNPFAE	LIG_APCC_ABBA_1	0.1389
p.Q318P	HCC2998	large_intestine	COSMIC	LNPFAE	LIG_APCC_ABBA_1	0.1389
p.D334N	ACH-001331	Head and Neck Cancer	CCLE	LNPFAE	LIG_APCC_ABBA_1	0.2222
p.D334N	BICR10	upper_aerodigestive_tract	COSMIC	LNPFAE	LIG_APCC_ABBA_1	0.2222
p.D320H	ACH-001459	Colon/Colorectal Cancer	CCLE	LNPFAE	LIG_APCC_ABBA_1	0.1944
p.D323Y	ACH-002193	Lung Cancer	CCLE	LNPFAE	LIG_APCC_ABBA_1	0.2778
p.D323Y	RERF-LC-FM	lung	COSMIC	LNPFAE	LIG_APCC_ABBA_1	0.2778
p.S316L	A172	central_nervous_system	COSMIC	LNPFAE	LIG_APCC_ABBA_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LNPFAE

Degron related mutations and impact score

Drug responses associated with RAPGEF5 mutations

All proteins holding degron of LNPFAE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92565	Rap guanine nucleotide exchange factor 5	LIG_APCC_ABBA_1	325:330	LNPFAE	APC,CDC20,FZR1	0.907	More...