DegronMD - Q92575(UBXN4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S448L	TCGA-AJ-A5DW	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.1667
p.S448L	DO50075	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.1667
p.A136V	TCGA-AM-5821	COAD	TCGA	VSTPSAS	DEG_SCF_FBW7_1	131:137	Mutation altering degron motif	0.5825
p.A136V	DO8240	COAD	ICGC	VSTPSAS	DEG_SCF_FBW7_1	131:137	Mutation altering degron motif	0.5825
p.A136V	SIDM00216	Colorectal Carcinoma	GDSC	VSTPSAS	DEG_SCF_FBW7_1	131:137	Mutation altering degron motif	0.5825
p.A136V	SNU-175	large intestine	COSMIC	VSTPSAS	DEG_SCF_FBW7_1	131:137	Mutation altering degron motif	0.5825
p.G124D	TCGA-B5-A11E	UCEC	TCGA	VSTPSAS	DEG_SCF_FBW7_1	131:137	Mutation rewiring degron network	0.1389
p.G124D	DO41644	UCEC	ICGC	VSTPSAS	DEG_SCF_FBW7_1	131:137	Mutation rewiring degron network	0.1389
p.E450K	TCGA-BB-4223	HNSC	TCGA	PASSS	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.2222
p.E450K	TCGA-RP-A693	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.2222
p.E450K	DO15607	HNSC	ICGC	PASSS	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.2222
p.E450K	DO51268	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.2222
p.S135F	TCGA-DU-6392	LGG	TCGA	VSTPSAS	DEG_SCF_FBW7_1	131:137	Mutation altering degron motif	0.6871
p.S135F	DO22237	LGG	ICGC	VSTPSAS	DEG_SCF_FBW7_1	131:137	Mutation altering degron motif	0.6871
p.P134T	TCGA-EE-A2MN	SKCM	TCGA	VSTPSAS	DEG_SCF_FBW7_1	131:137	Mutation altering degron motif	0.7031
p.P134T	DO37423	SKCM	ICGC	VSTPSAS	DEG_SCF_FBW7_1	131:137	Mutation altering degron motif	0.7031
p.G124C	TCGA-EE-A3AD	SKCM	TCGA	VSTPSAS	DEG_SCF_FBW7_1	131:137	Mutation rewiring degron network	0.1389
p.G124C	DO37707	SKCM	ICGC	VSTPSAS	DEG_SCF_FBW7_1	131:137	Mutation rewiring degron network	0.1389
p.F138C	TCGA-W5-AA39	CHOL	TCGA	VSTPSAS	DEG_SCF_FBW7_1	131:137	Mutation rewiring degron network	0.3056
p.P465L	DO222648	BTCA	ICGC	PASSS	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.1389
p.S458R	DO229005	COCA	ICGC	PASSS	DEG_SPOP_SBC_1	454:458	Mutation altering degron motif	0.7427
p.S458R	SIDM00291	Melanoma	GDSC	PASSS	DEG_SPOP_SBC_1	454:458	Mutation altering degron motif	0.7427
p.S458R	SIDM00375	Head and Neck Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	454:458	Mutation altering degron motif	0.7427
p.S458R	SIDM00292	Small Cell Lung Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	454:458	Mutation altering degron motif	0.7427
p.S458R	SIDM00988	Kidney Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	454:458	Mutation altering degron motif	0.7427
p.S458R	SIDM00167	Head and Neck Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	454:458	Mutation altering degron motif	0.7427
p.S458R	SIDM01753	Gastric Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	454:458	Mutation altering degron motif	0.7427
p.R445K	DO229027	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.0833
p.S456A	DO231518	LINC	ICGC	PASSS	DEG_SPOP_SBC_1	454:458	Mutation altering degron motif	0.87
p.S456L	SIDM00773	Non-Cancerous	GDSC	PASSS	DEG_SPOP_SBC_1	454:458	Mutation altering degron motif	0.8778
p.S456L	ACH-002381	Non-Cancerous	CCLE	PASSS	DEG_SPOP_SBC_1	454:458	Mutation altering degron motif	0.8778
p.E464G	SIDM00416	B-Cell Non-Hodgkin's Lymphoma	GDSC	PASSS	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.1667
p.E464G	ACH-001703	Lymphoma	CCLE	PASSS	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.1667
p.E464G	VAL	haematopoietic and lymphoid tissue	COSMIC	PASSS	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.1667

Kaplan plot for UBXN4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UBXN4

UniProt ID: Q92575

Entrez ID: 23190

Protein name: UBX domain-containing protein 4 (Erasin) (UBX domain-containing protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UBXN4 in