DegronMD

Uniprot ID: Q92575

Source protein: UBX domain-containing protein 4

Source gene: UBXN4

Class: DEG_SCF_FBW7_1

Location: 131:137

E3 ligase: FBXW7

DEGRON score: 0.9939

ASA_SCORE: 77.4286

COIL: 0.9073

CONS_SCORE: 0.3158

DSS_SCORE: 0.6223

HELIX: 0.0589

FCONS_SCORE: 0.9917

RIG_SCORE: 0.5918

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A136V	TCGA-AM-5821	COAD	TCGA	VSTPSAS	DEG_SCF_FBW7_1	0.5825
p.A136V	DO8240	COAD	ICGC	VSTPSAS	DEG_SCF_FBW7_1	0.5825
p.A136V	SIDM00216	Colorectal Carcinoma	GDSC	VSTPSAS	DEG_SCF_FBW7_1	0.5825
p.A136V	SNU-175	large_intestine	COSMIC	VSTPSAS	DEG_SCF_FBW7_1	0.5825
p.G124D	TCGA-B5-A11E	UCEC	TCGA	VSTPSAS	DEG_SCF_FBW7_1	0.1389
p.G124D	DO41644	UCEC	ICGC	VSTPSAS	DEG_SCF_FBW7_1	0.1389
p.S135F	TCGA-DU-6392	LGG	TCGA	VSTPSAS	DEG_SCF_FBW7_1	0.6871
p.S135F	DO22237	LGG	ICGC	VSTPSAS	DEG_SCF_FBW7_1	0.6871
p.P134T	TCGA-EE-A2MN	SKCM	TCGA	VSTPSAS	DEG_SCF_FBW7_1	0.7031
p.P134T	DO37423	SKCM	ICGC	VSTPSAS	DEG_SCF_FBW7_1	0.7031
p.G124C	TCGA-EE-A3AD	SKCM	TCGA	VSTPSAS	DEG_SCF_FBW7_1	0.1389
p.G124C	DO37707	SKCM	ICGC	VSTPSAS	DEG_SCF_FBW7_1	0.1389
p.F138C	TCGA-W5-AA39	CHOL	TCGA	VSTPSAS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92575	UBX domain-containing protein 4	DEG_SCF_FBW7_1	131:137	VSTPSAS	FBXW7	0.9939	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons