DegronMD - Q92599(SEPTIN8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E298K	SIDM02013	Colorectal Carcinoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.25
p.R302H	SIDM00061	Ovarian Carcinoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.8244
p.R302H	SIDM00705	Non-Cancerous	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.8244
p.R302H	SIDM00266	Ewing's Sarcoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.8244
p.R302H	SIDM01161	Other Sarcomas	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.8244
p.R302H	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.8244
p.R302H	SIDM00177	Melanoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.8244
p.R302H	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.8244
p.R302H	SIDM00049	Colorectal Carcinoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.8244
p.R302H	SIDM00724	Non-Small Cell Lung Carcinoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.8244
p.R302H	SIDM00638	Cervical Carcinoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.8244
p.R302H	SIDM01564	Colorectal Carcinoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.8244
p.P319L	SIDM01060	Melanoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.0556

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons