DegronMD

Uniprot ID: Q92599

Source protein: Septin-8

Source gene: SEPTIN8

Class: DEG_APCC_DBOX_1

Location: 301:309

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7385

ASA_SCORE: 68.4

COIL: 0.2094

CONS_SCORE: 0.6926

DSS_SCORE: 0.3159

HELIX: 0.7886

FCONS_SCORE: 1.1022

RIG_SCORE: 0.7749

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E298K	SIDM02013	Colorectal Carcinoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	0.25
p.R302H	SIDM00061	Ovarian Carcinoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	0.8244
p.R302H	SIDM00705	Non-Cancerous	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	0.8244
p.R302H	SIDM00266	Ewing's Sarcoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	0.8244
p.R302H	SIDM01161	Other Sarcomas	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	0.8244
p.R302H	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	0.8244
p.R302H	SIDM00177	Melanoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	0.8244
p.R302H	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	0.8244
p.R302H	SIDM00049	Colorectal Carcinoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	0.8244
p.R302H	SIDM00724	Non-Small Cell Lung Carcinoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	0.8244
p.R302H	SIDM00638	Cervical Carcinoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	0.8244
p.R302H	SIDM01564	Colorectal Carcinoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	0.8244
p.P319L	SIDM01060	Melanoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons