DegronMD - Q9NVA2(SEPTIN11)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T299N	SIDM00057	Neuroblastoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	298:306	Mutation altering degron motif	0.7055
p.T299N	SIDM00552	Rhabdomyosarcoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	298:306	Mutation altering degron motif	0.7055
p.E314K	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	298:306	Mutation blocking phosphorylation signal	0.5556
p.Y307H	SIDM00537	Colorectal Carcinoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	298:306	Mutation rewiring degron network	0.3056
p.R302H	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	298:306	Mutation altering degron motif	0.8244
p.R289H	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	298:306	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons