DegronMD

Uniprot ID: Q9NVA2

Source protein: Septin-11

Source gene: SEPTIN11

Class: DEG_APCC_DBOX_1

Location: 298:306

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8656

ASA_SCORE: 67.9

COIL: 0.222

CONS_SCORE: 0.711

DSS_SCORE: 0.2967

HELIX: 0.7768

FCONS_SCORE: 1.1293

RIG_SCORE: 0.7838

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T299N	SIDM00057	Neuroblastoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	0.7055
p.T299N	SIDM00552	Rhabdomyosarcoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	0.7055
p.E314K	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	0.5556
p.Y307H	SIDM00537	Colorectal Carcinoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	0.3056
p.R302H	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	0.8244
p.R289H	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRCKLEEMG	DEG_APCC_DBOX_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons