DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
RRCKLEEMG
Uniprot ID:
Q9P0V9
Source protein:
Septin-10
Source gene:
SEPTIN10
Class:
DEG_APCC_DBOX_1
Location:
323:331
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.53
ASA_SCORE:
68.8222
COIL:
0.2068
CONS_SCORE:
0.7244
DSS_SCORE:
0.247
HELIX:
0.7916
FCONS_SCORE:
1.1195
RIG_SCORE:
0.8027
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R324H
SIDM00654
Small Cell Lung Carcinoma
GDSC
RRCKLEEMG
DEG_APCC_DBOX_1
0.8244
Drug responses associated with SEPTIN10 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RRCKLEEMG
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q92599
Septin-8
DEG_APCC_DBOX_1
301:309
RRCKLEEMG
APC,CDC20,FZR1
0.7385
More...
Q9NVA2
Septin-11
DEG_APCC_DBOX_1
298:306
RRCKLEEMG
APC,CDC20,FZR1
0.8656
More...
Q9P0V9
Septin-10
DEG_APCC_DBOX_1
323:331
RRCKLEEMG
APC,CDC20,FZR1
0.53
More...