DegronMD - Q92608(DOCK2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T1675M	TCGA-27-2523	GBM	TCGA	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation altering degron motif	0.8534
p.T1675M	TCGA-5M-AAT6	COAD	TCGA	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation altering degron motif	0.8534
p.T1675M	TCGA-61-1727	OV	TCGA	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation altering degron motif	0.8534
p.T1675M	TCGA-UF-A71E	HNSC	TCGA	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation altering degron motif	0.8534
p.T1675M	TCGA-VQ-A91A	STAD	TCGA	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation altering degron motif	0.8534
p.T1675M	DO223703	COAD	ICGC	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation altering degron motif	0.8534
p.T1675M	DO11441	GBM	ICGC	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation altering degron motif	0.8534
p.T1675M	DO10908	GBM	ICGC	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation altering degron motif	0.8534
p.T1675M	DO52110	HNSC	ICGC	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation altering degron motif	0.8534
p.T1675M	DO29960	OV	ICGC	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation altering degron motif	0.8534
p.T1675M	DO51781	STAD	ICGC	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation altering degron motif	0.8534
p.S1665C	TCGA-78-8662	LUAD	TCGA	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation rewiring degron network	0.1111
p.S1665C	DO45346	LUAD	ICGC	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation rewiring degron network	0.1111
p.E1681D	TCGA-85-7950	LUSC	TCGA	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation rewiring degron network	0.2778
p.E1681D	DO26878	LUSC	ICGC	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation rewiring degron network	0.2778
p.P1686L	TCGA-A5-A0G2	UCEC	TCGA	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation rewiring degron network	0.1389
p.P1686L	DO51498	PACA	ICGC	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation rewiring degron network	0.1389
p.P1686L	DO41235	UCEC	ICGC	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation rewiring degron network	0.1389
p.P1686S	TCGA-EE-A29E	SKCM	TCGA	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation rewiring degron network	0.1389
p.P1686S	DO37831	SKCM	ICGC	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation rewiring degron network	0.1389
p.S1685F	TCGA-EE-A2MS	SKCM	TCGA	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation blocking phosphorylation signal	0.6111
p.S1685F	DO37567	SKCM	ICGC	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation blocking phosphorylation signal	0.6111
p.G1687E	TCGA-GN-A4U5	SKCM	TCGA	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation rewiring degron network	0.1111
p.G1687E	DO51257	SKCM	ICGC	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation rewiring degron network	0.1111
p.K1674N	TCGA-L5-A8NS	ESCA	TCGA	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation altering degron motif	0.5806
p.R1677I	TCGA-QF-A5YS	UCEC	TCGA	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation altering degron motif	0.6991
p.R1677I	DO52426	UCEC	ICGC	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation altering degron motif	0.6991
p.A1671V	DO222817	BTCA	ICGC	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation rewiring degron network	0.2778
p.L1670F	DO220894	MELA	ICGC	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation rewiring degron network	0.25
p.P1683L	SIDM00570	Gastric Carcinoma	GDSC	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation rewiring degron network	0.2222
p.P1683L	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation rewiring degron network	0.2222
p.P1683L	SIDM00282	Colorectal Carcinoma	GDSC	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation rewiring degron network	0.2222
p.P1683L	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation rewiring degron network	0.2222
p.P1683L	SIDM00316	Glioblastoma	GDSC	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation rewiring degron network	0.2222
p.P1683L	SIDM01662	Plasma Cell Myeloma	GDSC	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation rewiring degron network	0.2222
p.P1683L	SIDM01473	Plasma Cell Myeloma	GDSC	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation rewiring degron network	0.2222
p.P1683L	YH-13	central nervous system	COSMIC	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation rewiring degron network	0.2222
p.P1683L	CW-2	large intestine	COSMIC	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation rewiring degron network	0.2222
p.P1683L	TE-1	oesophagus	COSMIC	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation rewiring degron network	0.2222
p.S1688R	SIDM00447	B-Lymphoblastic Leukemia	GDSC	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation blocking phosphorylation signal	0.5278
p.P1676R	SIDM00257	Neuroblastoma	GDSC	PKTPRVE	DEG_SCF_FBW7_2	1673:1679	Mutation altering degron motif	0.7512

Kaplan plot for DOCK2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DOCK2

UniProt ID: Q92608

Entrez ID: 1794

Protein name: Dedicator of cytokinesis protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DOCK2 in