DegronMD

Uniprot ID: Q92608

Source protein: Dedicator of cytokinesis protein 2

Source gene: DOCK2

Class: DEG_SCF_FBW7_2

Location: 1673:1679

E3 ligase: FBXW7

DEGRON score: 0.879

ASA_SCORE: 109.7857

COIL: 0.8841

CONS_SCORE: 0.2257

DSS_SCORE: 0.6296

HELIX: 0.087

FCONS_SCORE: 0.9263

RIG_SCORE: 0.6374

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1675M	TCGA-27-2523	GBM	TCGA	PKTPRVE	DEG_SCF_FBW7_2	0.8534
p.T1675M	TCGA-5M-AAT6	COAD	TCGA	PKTPRVE	DEG_SCF_FBW7_2	0.8534
p.T1675M	TCGA-61-1727	OV	TCGA	PKTPRVE	DEG_SCF_FBW7_2	0.8534
p.T1675M	TCGA-UF-A71E	HNSC	TCGA	PKTPRVE	DEG_SCF_FBW7_2	0.8534
p.T1675M	TCGA-VQ-A91A	STAD	TCGA	PKTPRVE	DEG_SCF_FBW7_2	0.8534
p.T1675M	DO223703	COAD	ICGC	PKTPRVE	DEG_SCF_FBW7_2	0.8534
p.T1675M	DO11441	GBM	ICGC	PKTPRVE	DEG_SCF_FBW7_2	0.8534
p.T1675M	DO10908	GBM	ICGC	PKTPRVE	DEG_SCF_FBW7_2	0.8534
p.T1675M	DO52110	HNSC	ICGC	PKTPRVE	DEG_SCF_FBW7_2	0.8534
p.T1675M	DO29960	OV	ICGC	PKTPRVE	DEG_SCF_FBW7_2	0.8534
p.T1675M	DO51781	STAD	ICGC	PKTPRVE	DEG_SCF_FBW7_2	0.8534
p.S1665C	TCGA-78-8662	LUAD	TCGA	PKTPRVE	DEG_SCF_FBW7_2	0.1111
p.S1665C	DO45346	LUAD	ICGC	PKTPRVE	DEG_SCF_FBW7_2	0.1111
p.E1681D	TCGA-85-7950	LUSC	TCGA	PKTPRVE	DEG_SCF_FBW7_2	0.2778
p.E1681D	DO26878	LUSC	ICGC	PKTPRVE	DEG_SCF_FBW7_2	0.2778
p.P1686L	TCGA-A5-A0G2	UCEC	TCGA	PKTPRVE	DEG_SCF_FBW7_2	0.1389
p.P1686L	DO51498	PACA	ICGC	PKTPRVE	DEG_SCF_FBW7_2	0.1389
p.P1686L	DO41235	UCEC	ICGC	PKTPRVE	DEG_SCF_FBW7_2	0.1389
p.P1686S	TCGA-EE-A29E	SKCM	TCGA	PKTPRVE	DEG_SCF_FBW7_2	0.1389
p.P1686S	DO37831	SKCM	ICGC	PKTPRVE	DEG_SCF_FBW7_2	0.1389
p.S1685F	TCGA-EE-A2MS	SKCM	TCGA	PKTPRVE	DEG_SCF_FBW7_2	0.6111
p.S1685F	DO37567	SKCM	ICGC	PKTPRVE	DEG_SCF_FBW7_2	0.6111
p.G1687E	TCGA-GN-A4U5	SKCM	TCGA	PKTPRVE	DEG_SCF_FBW7_2	0.1111
p.G1687E	DO51257	SKCM	ICGC	PKTPRVE	DEG_SCF_FBW7_2	0.1111
p.K1674N	TCGA-L5-A8NS	ESCA	TCGA	PKTPRVE	DEG_SCF_FBW7_2	0.5806
p.R1677I	TCGA-QF-A5YS	UCEC	TCGA	PKTPRVE	DEG_SCF_FBW7_2	0.6991
p.R1677I	DO52426	UCEC	ICGC	PKTPRVE	DEG_SCF_FBW7_2	0.6991
p.A1671V	DO222817	BTCA	ICGC	PKTPRVE	DEG_SCF_FBW7_2	0.2778
p.L1670F	DO220894	MELA	ICGC	PKTPRVE	DEG_SCF_FBW7_2	0.25
p.P1683L	SIDM00570	Gastric Carcinoma	GDSC	PKTPRVE	DEG_SCF_FBW7_2	0.2222
p.P1683L	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	PKTPRVE	DEG_SCF_FBW7_2	0.2222
p.P1683L	SIDM00282	Colorectal Carcinoma	GDSC	PKTPRVE	DEG_SCF_FBW7_2	0.2222
p.P1683L	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	PKTPRVE	DEG_SCF_FBW7_2	0.2222
p.P1683L	SIDM00316	Glioblastoma	GDSC	PKTPRVE	DEG_SCF_FBW7_2	0.2222
p.P1683L	SIDM01662	Plasma Cell Myeloma	GDSC	PKTPRVE	DEG_SCF_FBW7_2	0.2222
p.P1683L	SIDM01473	Plasma Cell Myeloma	GDSC	PKTPRVE	DEG_SCF_FBW7_2	0.2222
p.P1683L	YH-13	central_nervous_system	COSMIC	PKTPRVE	DEG_SCF_FBW7_2	0.2222
p.P1683L	CW-2	large_intestine	COSMIC	PKTPRVE	DEG_SCF_FBW7_2	0.2222
p.P1683L	TE-1	oesophagus	COSMIC	PKTPRVE	DEG_SCF_FBW7_2	0.2222
p.S1688R	SIDM00447	B-Lymphoblastic Leukemia	GDSC	PKTPRVE	DEG_SCF_FBW7_2	0.5278
p.P1676R	SIDM00257	Neuroblastoma	GDSC	PKTPRVE	DEG_SCF_FBW7_2	0.7512

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PKTPRVE

Degron related mutations and impact score

Drug responses associated with DOCK2 mutations

All proteins holding degron of PKTPRVE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92608	Dedicator of cytokinesis protein 2	DEG_SCF_FBW7_2	1673:1679	PKTPRVE	FBXW7	0.879	More...