DegronMD - Q92611(EDEM1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P29S	TCGA-A6-5661	COAD	TCGA	LRLGLHGVL	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1111
p.P29S	DO8634	COAD	ICGC	LRLGLHGVL	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1111
p.S4L	DO590	BLCA	ICGC	LRLGLHGVL	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.0833
p.N3I	DO44832	LICA	ICGC	LRLGLHGVL	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.0556
p.S19L	DO219468	SKCM	ICGC	LRLGLHGVL	DEG_APCC_DBOX_1	13:21	Mutation altering degron motif	0.7667
p.D21N	DO47769	STAD	ICGC	LRLGLHGVL	DEG_APCC_DBOX_1	13:21	Mutation altering degron motif	0.6932
p.G16V	DO229272	THCA	ICGC	LRLGLHGVL	DEG_APCC_DBOX_1	13:21	Mutation altering degron motif	0.6421
p.L17P	DO229242	THCA	ICGC	LRLGLHGVL	DEG_APCC_DBOX_1	13:21	Mutation altering degron motif	0.7582
p.D23Y	DO52412	UCEC	ICGC	LRLGLHGVL	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.2778
p.W3C	SIDM01233	Colorectal Carcinoma	GDSC	LRLGLHGVL	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.0556
p.V11A	SIDM00498	Colorectal Carcinoma	GDSC	LRLGLHGVL	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.2778
p.V11A	ACH-000970	Colon/Colorectal Cancer	CCLE	LRLGLHGVL	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons