DegronMD

Uniprot ID: Q92611

Source protein: ER degradation-enhancing alpha-mannosidase-like protein 1

Source gene: EDEM1

Class: DEG_APCC_DBOX_1

Location: 13:21

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6741

ASA_SCORE: 51.2889

COIL: 0.0328

CONS_SCORE: 0.2386

DSS_SCORE: 0.0001

HELIX: 0.9639

FCONS_SCORE: 1.3121

RIG_SCORE: 0.9444

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P29S	TCGA-A6-5661	COAD	TCGA	LRLGLHGVL	DEG_APCC_DBOX_1	0.1111
p.P29S	DO8634	COAD	ICGC	LRLGLHGVL	DEG_APCC_DBOX_1	0.1111
p.S4L	DO590	BLCA	ICGC	LRLGLHGVL	DEG_APCC_DBOX_1	0.0833
p.N3I	DO44832	LICA	ICGC	LRLGLHGVL	DEG_APCC_DBOX_1	0.0556
p.S19L	DO219468	SKCM	ICGC	LRLGLHGVL	DEG_APCC_DBOX_1	0.7667
p.D21N	DO47769	STAD	ICGC	LRLGLHGVL	DEG_APCC_DBOX_1	0.6932
p.G16V	DO229272	THCA	ICGC	LRLGLHGVL	DEG_APCC_DBOX_1	0.6421
p.L17P	DO229242	THCA	ICGC	LRLGLHGVL	DEG_APCC_DBOX_1	0.7582
p.D23Y	DO52412	UCEC	ICGC	LRLGLHGVL	DEG_APCC_DBOX_1	0.2778
p.W3C	SIDM01233	Colorectal Carcinoma	GDSC	LRLGLHGVL	DEG_APCC_DBOX_1	0.0556
p.V11A	SIDM00498	Colorectal Carcinoma	GDSC	LRLGLHGVL	DEG_APCC_DBOX_1	0.2778
p.V11A	ACH-000970	Colon/Colorectal Cancer	CCLE	LRLGLHGVL	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92611	ER degradation-enhancing alpha-mannosidase-like protein 1	DEG_APCC_DBOX_1	13:21	LRLGLHGVL	APC,CDC20,FZR1	0.6741	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons