DegronMD - Q92614(MYO18A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S103R	TCGA-04-1342	OV	TCGA	DSGHLST	DEG_SCF_TRCP1_1	93:99	Mutation blocking phosphorylation signal	0.6667
p.S103R	DO29548	OV	ICGC	DSGHLST	DEG_SCF_TRCP1_1	93:99	Mutation blocking phosphorylation signal	0.6667
p.L106F	TCGA-61-1737	OV	TCGA	DSGHLST	DEG_SCF_TRCP1_1	93:99	Mutation rewiring degron network	0.1389
p.L106F	DO30620	OV	ICGC	DSGHLST	DEG_SCF_TRCP1_1	93:99	Mutation rewiring degron network	0.1389
p.D84N	TCGA-AA-A01P	COAD	TCGA	DSGHLST	DEG_SCF_TRCP1_1	93:99	Mutation rewiring degron network	0.0833
p.D84N	DO8642	COAD	ICGC	DSGHLST	DEG_SCF_TRCP1_1	93:99	Mutation rewiring degron network	0.0833
p.R87W	TCGA-AP-A0LM	UCEC	TCGA	DSGHLST	DEG_SCF_TRCP1_1	93:99	Mutation rewiring degron network	0.1667
p.R87W	DO220908	MELA	ICGC	DSGHLST	DEG_SCF_TRCP1_1	93:99	Mutation rewiring degron network	0.1667
p.R87W	DO43306	UCEC	ICGC	DSGHLST	DEG_SCF_TRCP1_1	93:99	Mutation rewiring degron network	0.1667
p.V90I	TCGA-FI-A2D0	UCEC	TCGA	DSGHLST	DEG_SCF_TRCP1_1	93:99	Mutation rewiring degron network	0.25
p.V90I	DO233168	GACA	ICGC	DSGHLST	DEG_SCF_TRCP1_1	93:99	Mutation rewiring degron network	0.25
p.V90I	DO43891	UCEC	ICGC	DSGHLST	DEG_SCF_TRCP1_1	93:99	Mutation rewiring degron network	0.25
p.A100V	DO230312	COCA	ICGC	DSGHLST	DEG_SCF_TRCP1_1	93:99	Mutation rewiring degron network	0.3056
p.S94L	DO233748	GACA	ICGC	DSGHLST	DEG_SCF_TRCP1_1	93:99	Mutation altering degron motif	0.8778
p.G95C	DO233823	GACA	ICGC	DSGHLST	DEG_SCF_TRCP1_1	93:99	Mutation altering degron motif	0.76
p.S83C	SIDM01312	Esophageal Carcinoma	GDSC	DSGHLST	DEG_SCF_TRCP1_1	93:99	Mutation blocking phosphorylation signal	0.5
p.S102T	SIDM00846	Cervical Carcinoma	GDSC	DSGHLST	DEG_SCF_TRCP1_1	93:99	Mutation blocking phosphorylation signal	0.6944
p.S102T	ACH-001086	Cervical Cancer	CCLE	DSGHLST	DEG_SCF_TRCP1_1	93:99	Mutation blocking phosphorylation signal	0.6944
p.S102T	HeLa	cervix	COSMIC	DSGHLST	DEG_SCF_TRCP1_1	93:99	Mutation blocking phosphorylation signal	0.6944
p.S102C	ACH-000975	Lung Cancer	CCLE	DSGHLST	DEG_SCF_TRCP1_1	93:99	Mutation blocking phosphorylation signal	0.6944

Kaplan plot for MYO18A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYO18A

UniProt ID: Q92614

Entrez ID: 399687

Protein name: Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYO18A in