DegronMD

Uniprot ID: Q92614

Source protein: Unconventional myosin-XVIIIa

Source gene: MYO18A

Class: DEG_SCF_TRCP1_1

Location: 93:99

E3 ligase: BTRC

DEGRON score: 0.9994

ASA_SCORE: 74.5286

COIL: 0.8394

CONS_SCORE: 0.3089

DSS_SCORE: 0.4546

HELIX: 0.0647

FCONS_SCORE: 0.9927

RIG_SCORE: 0.6665

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S103R	TCGA-04-1342	OV	TCGA	DSGHLST	DEG_SCF_TRCP1_1	0.6667
p.S103R	DO29548	OV	ICGC	DSGHLST	DEG_SCF_TRCP1_1	0.6667
p.L106F	TCGA-61-1737	OV	TCGA	DSGHLST	DEG_SCF_TRCP1_1	0.1389
p.L106F	DO30620	OV	ICGC	DSGHLST	DEG_SCF_TRCP1_1	0.1389
p.D84N	TCGA-AA-A01P	COAD	TCGA	DSGHLST	DEG_SCF_TRCP1_1	0.0833
p.D84N	DO8642	COAD	ICGC	DSGHLST	DEG_SCF_TRCP1_1	0.0833
p.R87W	TCGA-AP-A0LM	UCEC	TCGA	DSGHLST	DEG_SCF_TRCP1_1	0.1667
p.R87W	DO220908	MELA	ICGC	DSGHLST	DEG_SCF_TRCP1_1	0.1667
p.R87W	DO43306	UCEC	ICGC	DSGHLST	DEG_SCF_TRCP1_1	0.1667
p.V90I	TCGA-FI-A2D0	UCEC	TCGA	DSGHLST	DEG_SCF_TRCP1_1	0.25
p.V90I	DO233168	GACA	ICGC	DSGHLST	DEG_SCF_TRCP1_1	0.25
p.V90I	DO43891	UCEC	ICGC	DSGHLST	DEG_SCF_TRCP1_1	0.25
p.A100V	DO230312	COCA	ICGC	DSGHLST	DEG_SCF_TRCP1_1	0.3056
p.S94L	DO233748	GACA	ICGC	DSGHLST	DEG_SCF_TRCP1_1	0.8778
p.G95C	DO233823	GACA	ICGC	DSGHLST	DEG_SCF_TRCP1_1	0.76
p.S83C	SIDM01312	Esophageal Carcinoma	GDSC	DSGHLST	DEG_SCF_TRCP1_1	0.5
p.S102T	SIDM00846	Cervical Carcinoma	GDSC	DSGHLST	DEG_SCF_TRCP1_1	0.6944
p.S102T	ACH-001086	Cervical Cancer	CCLE	DSGHLST	DEG_SCF_TRCP1_1	0.6944
p.S102T	HeLa	cervix	COSMIC	DSGHLST	DEG_SCF_TRCP1_1	0.6944
p.S102C	ACH-000975	Lung Cancer	CCLE	DSGHLST	DEG_SCF_TRCP1_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92614	Unconventional myosin-XVIIIa	DEG_SCF_TRCP1_1	93:99	DSGHLST	BTRC	0.9994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons