DegronMD - Q92621(NUP205)

NUP205

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1180Q	TCGA-CD-5813	STAD	TCGA	RRKILNILD	DEG_APCC_DBOX_1	1179:1187	Mutation altering degron motif	0.7329
p.R1180Q	DO38259	STAD	ICGC	RRKILNILD	DEG_APCC_DBOX_1	1179:1187	Mutation altering degron motif	0.7329
p.R1180Q	SIDM00534	Colorectal Carcinoma	GDSC	RRKILNILD	DEG_APCC_DBOX_1	1179:1187	Mutation altering degron motif	0.7329
p.R1180Q	HT-115	large intestine	COSMIC	RRKILNILD	DEG_APCC_DBOX_1	1179:1187	Mutation altering degron motif	0.7329
p.K1177T	TCGA-E6-A1LX	UCEC	TCGA	RRKILNILD	DEG_APCC_DBOX_1	1179:1187	Mutation blocking ubiquitination signal	0.7222
p.K1177T	DO41020	UCEC	ICGC	RRKILNILD	DEG_APCC_DBOX_1	1179:1187	Mutation blocking ubiquitination signal	0.7222
p.T1176A	TCGA-VQ-AA6D	STAD	TCGA	RRKILNILD	DEG_APCC_DBOX_1	1179:1187	Mutation rewiring degron network	0.25
p.T1176A	DO222392	STAD	ICGC	RRKILNILD	DEG_APCC_DBOX_1	1179:1187	Mutation rewiring degron network	0.25
p.R1179C	DO23486	LINC	ICGC	RRKILNILD	DEG_APCC_DBOX_1	1179:1187	Mutation altering degron motif	0.719
p.S1188L	DO228657	PRAD	ICGC	RRKILNILD	DEG_APCC_DBOX_1	1179:1187	Mutation rewiring degron network	0.3056
p.E1197K	DO37432	SKCM	ICGC	RRKILNILD	DEG_APCC_DBOX_1	1179:1187	Mutation rewiring degron network	0.0556

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*NOTE: the Kaplan plots were collected from OncoLnc