DegronMD

Uniprot ID: Q92621

Source protein: Nuclear pore complex protein Nup205

Source gene: NUP205

Class: DEG_APCC_DBOX_1

Location: 1179:1187

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6015

ASA_SCORE: 48.0111

COIL: 0.1993

CONS_SCORE: 0.4599

DSS_SCORE: 0.0945

HELIX: 0.7692

FCONS_SCORE: 1.4506

RIG_SCORE: 0.8835

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1180Q	TCGA-CD-5813	STAD	TCGA	RRKILNILD	DEG_APCC_DBOX_1	0.7329
p.R1180Q	DO38259	STAD	ICGC	RRKILNILD	DEG_APCC_DBOX_1	0.7329
p.R1180Q	SIDM00534	Colorectal Carcinoma	GDSC	RRKILNILD	DEG_APCC_DBOX_1	0.7329
p.R1180Q	HT-115	large_intestine	COSMIC	RRKILNILD	DEG_APCC_DBOX_1	0.7329
p.K1177T	TCGA-E6-A1LX	UCEC	TCGA	RRKILNILD	DEG_APCC_DBOX_1	0.7222
p.K1177T	DO41020	UCEC	ICGC	RRKILNILD	DEG_APCC_DBOX_1	0.7222
p.T1176A	TCGA-VQ-AA6D	STAD	TCGA	RRKILNILD	DEG_APCC_DBOX_1	0.25
p.T1176A	DO222392	STAD	ICGC	RRKILNILD	DEG_APCC_DBOX_1	0.25
p.R1179C	DO23486	LINC	ICGC	RRKILNILD	DEG_APCC_DBOX_1	0.719
p.S1188L	DO228657	PRAD	ICGC	RRKILNILD	DEG_APCC_DBOX_1	0.3056
p.E1197K	DO37432	SKCM	ICGC	RRKILNILD	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92621	Nuclear pore complex protein Nup205	DEG_APCC_DBOX_1	1179:1187	RRKILNILD	APC,CDC20,FZR1	0.6015	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons