DegronMD - Q92625(ANKS1A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E659D	TCGA-E6-A1LX	UCEC	TCGA	FASEWDEI	DEG_MDM2_SWIB_1	664:671	Mutation rewiring degron network	0.1944
p.E659D	DO41020	UCEC	ICGC	FASEWDEI	DEG_MDM2_SWIB_1	664:671	Mutation rewiring degron network	0.1944
p.E672K	TCGA-E7-A7DU	BLCA	TCGA	FASEWDEI	DEG_MDM2_SWIB_1	664:671	Mutation rewiring degron network	0.3056
p.E672K	DO219016	BLCA	ICGC	FASEWDEI	DEG_MDM2_SWIB_1	664:671	Mutation rewiring degron network	0.3056
p.S666L	TCGA-IG-A50L	ESCA	TCGA	FASEWDEI	DEG_MDM2_SWIB_1	664:671	Mutation altering degron motif	0.7667
p.E680K	TCGA-N9-A4Q7	UCS	TCGA	FASEWDEI	DEG_MDM2_SWIB_1	664:671	Mutation rewiring degron network	0.0833
p.E680Q	TCGA-S5-A6DX	BLCA	TCGA	FASEWDEI	DEG_MDM2_SWIB_1	664:671	Mutation rewiring degron network	0.0833
p.E680Q	DO51903	BLCA	ICGC	FASEWDEI	DEG_MDM2_SWIB_1	664:671	Mutation rewiring degron network	0.0833
p.R657M	DO233865	GACA	ICGC	FASEWDEI	DEG_MDM2_SWIB_1	664:671	Mutation rewiring degron network	0.1389
p.S677Y	SIDM00118	Colorectal Carcinoma	GDSC	FASEWDEI	DEG_MDM2_SWIB_1	664:671	Mutation blocking phosphorylation signal	0.6111
p.S677Y	ACH-001081	Colon/Colorectal Cancer	CCLE	FASEWDEI	DEG_MDM2_SWIB_1	664:671	Mutation blocking phosphorylation signal	0.6111
p.S677Y	HCC2998	large intestine	COSMIC	FASEWDEI	DEG_MDM2_SWIB_1	664:671	Mutation blocking phosphorylation signal	0.6111
p.A665T	ACH-000836	Head and Neck Cancer	CCLE	FASEWDEI	DEG_MDM2_SWIB_1	664:671	Mutation altering degron motif	0.6028
p.I678V	ACH-001518	Endometrial/Uterine Cancer	CCLE	FASEWDEI	DEG_MDM2_SWIB_1	664:671	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons