DegronMD

Uniprot ID: Q92625

Source protein: Ankyrin repeat and SAM domain-containing protein 1A

Source gene: ANKS1A

Class: DEG_MDM2_SWIB_1

Location: 664:671

E3 ligase: MDM2

DEGRON score: 0.9902

ASA_SCORE: 60.7125

COIL: 0.3079

CONS_SCORE: 0.4135

DSS_SCORE: 0.4152

HELIX: 0.69

FCONS_SCORE: 1.0415

RIG_SCORE: 0.7793

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E659D	TCGA-E6-A1LX	UCEC	TCGA	FASEWDEI	DEG_MDM2_SWIB_1	0.1944
p.E659D	DO41020	UCEC	ICGC	FASEWDEI	DEG_MDM2_SWIB_1	0.1944
p.E672K	TCGA-E7-A7DU	BLCA	TCGA	FASEWDEI	DEG_MDM2_SWIB_1	0.3056
p.E672K	DO219016	BLCA	ICGC	FASEWDEI	DEG_MDM2_SWIB_1	0.3056
p.S666L	TCGA-IG-A50L	ESCA	TCGA	FASEWDEI	DEG_MDM2_SWIB_1	0.7667
p.E680K	TCGA-N9-A4Q7	UCS	TCGA	FASEWDEI	DEG_MDM2_SWIB_1	0.0833
p.E680Q	TCGA-S5-A6DX	BLCA	TCGA	FASEWDEI	DEG_MDM2_SWIB_1	0.0833
p.E680Q	DO51903	BLCA	ICGC	FASEWDEI	DEG_MDM2_SWIB_1	0.0833
p.R657M	DO233865	GACA	ICGC	FASEWDEI	DEG_MDM2_SWIB_1	0.1389
p.S677Y	SIDM00118	Colorectal Carcinoma	GDSC	FASEWDEI	DEG_MDM2_SWIB_1	0.6111
p.S677Y	ACH-001081	Colon/Colorectal Cancer	CCLE	FASEWDEI	DEG_MDM2_SWIB_1	0.6111
p.S677Y	HCC2998	large_intestine	COSMIC	FASEWDEI	DEG_MDM2_SWIB_1	0.6111
p.A665T	ACH-000836	Head and Neck Cancer	CCLE	FASEWDEI	DEG_MDM2_SWIB_1	0.6028
p.I678V	ACH-001518	Endometrial/Uterine Cancer	CCLE	FASEWDEI	DEG_MDM2_SWIB_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92625	Ankyrin repeat and SAM domain-containing protein 1A	DEG_MDM2_SWIB_1	664:671	FASEWDEI	MDM2	0.9902	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons