DegronMD - Q92686(NRGN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R38W	TCGA-BF-A3DL	SKCM	TCGA	IQASFRGHMAR	SCF_FBXL2	33:43	Mutation altering degron motif	0.8634
p.R38W	DO51238	SKCM	ICGC	IQASFRGHMAR	SCF_FBXL2	33:43	Mutation altering degron motif	0.8634
p.A28E	TCGA-DM-A28K	COAD	TCGA	IQASFRGHMAR	SCF_FBXL2	33:43	Mutation rewiring degron network	0.1944
p.A28E	DO8167	COAD	ICGC	IQASFRGHMAR	SCF_FBXL2	33:43	Mutation rewiring degron network	0.1944
p.A31T	TCGA-FI-A2D5	UCEC	TCGA	IQASFRGHMAR	SCF_FBXL2	33:43	Mutation rewiring degron network	0.2778
p.A31T	DO41331	UCEC	ICGC	IQASFRGHMAR	SCF_FBXL2	33:43	Mutation rewiring degron network	0.2778
p.A28V	DO233146	GACA	ICGC	IQASFRGHMAR	SCF_FBXL2	33:43	Mutation rewiring degron network	0.1944
p.A28V	ACH-001518	Endometrial/Uterine Cancer	CCLE	IQASFRGHMAR	SCF_FBXL2	33:43	Mutation rewiring degron network	0.1944
p.G52S	DO233154	GACA	ICGC	IQASFRGHMAR	SCF_FBXL2	33:43	Mutation rewiring degron network	0.0833
p.R38Q	DO233154	GACA	ICGC	IQASFRGHMAR	SCF_FBXL2	33:43	Mutation altering degron motif	0.7329
p.G49V	DO229218	THCA	ICGC	IQASFRGHMAR	SCF_FBXL2	33:43	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons