DegronMD

Uniprot ID: Q92686

Source protein: Neurogranin

Source gene: NRGN

Class: SCF_FBXL2

Location: 33:43

E3 ligase: FBXL2

DEGRON score: 0.9233

ASA_SCORE: 73.4636

COIL: 0.388

CONS_SCORE: 1

DSS_SCORE: 0.5596

HELIX: 0.5965

FCONS_SCORE: 1.0141

RIG_SCORE: 0.7321

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R38W	TCGA-BF-A3DL	SKCM	TCGA	IQASFRGHMAR	SCF_FBXL2	0.8634
p.R38W	DO51238	SKCM	ICGC	IQASFRGHMAR	SCF_FBXL2	0.8634
p.A28E	TCGA-DM-A28K	COAD	TCGA	IQASFRGHMAR	SCF_FBXL2	0.1944
p.A28E	DO8167	COAD	ICGC	IQASFRGHMAR	SCF_FBXL2	0.1944
p.A31T	TCGA-FI-A2D5	UCEC	TCGA	IQASFRGHMAR	SCF_FBXL2	0.2778
p.A31T	DO41331	UCEC	ICGC	IQASFRGHMAR	SCF_FBXL2	0.2778
p.A28V	DO233146	GACA	ICGC	IQASFRGHMAR	SCF_FBXL2	0.1944
p.A28V	ACH-001518	Endometrial/Uterine Cancer	CCLE	IQASFRGHMAR	SCF_FBXL2	0.1944
p.G52S	DO233154	GACA	ICGC	IQASFRGHMAR	SCF_FBXL2	0.0833
p.R38Q	DO233154	GACA	ICGC	IQASFRGHMAR	SCF_FBXL2	0.7329
p.G49V	DO229218	THCA	ICGC	IQASFRGHMAR	SCF_FBXL2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92686	Neurogranin	SCF_FBXL2	33:43	IQASFRGHMAR	FBXL2	0.9233	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons