DegronMD - Q92752(TNR)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P658T	TCGA-17-Z022	LUAD	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.3056
p.V664F	TCGA-39-5040	LUSC	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.1389
p.V664F	DO45436	LUSC	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.1389
p.V639L	TCGA-44-5644	LUAD	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.0556
p.V639L	DO25153	LUAD	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.0556
p.L653M	TCGA-56-7730	LUSC	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation altering degron motif	0.711
p.L653M	TCGA-FS-A1ZJ	SKCM	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation altering degron motif	0.711
p.L653M	DO26617	LUSC	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation altering degron motif	0.711
p.L653M	DO37956	SKCM	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation altering degron motif	0.711
p.G644C	TCGA-6A-AB49	LUSC	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.1944
p.G644C	DO52020	LUSC	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.1944
p.G646R	TCGA-77-6842	LUSC	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.25
p.G646R	DO27413	LUSC	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.25
p.P642T	TCGA-BK-A139	UCEC	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.1389
p.P642T	TCGA-NJ-A4YQ	LUAD	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.1389
p.P642T	DO218944	LUAD	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.1389
p.P642T	DO41716	UCEC	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.1389
p.G644D	TCGA-D3-A8GM	SKCM	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.1944
p.G644D	DO50288	SKCM	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.1944
p.V657I	TCGA-DU-5870	LGG	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation altering degron motif	0.5965
p.V657I	DO22199	LGG	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation altering degron motif	0.5965
p.P647L	TCGA-EB-A3XD	SKCM	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.2778
p.P647L	DO37871	SKCM	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.2778
p.G663R	TCGA-EE-A2ME	SKCM	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.1667
p.G663R	DO38011	SKCM	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.1667
p.T648I	TCGA-EE-A3AG	SKCM	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.3056
p.T648I	DO37471	SKCM	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.3056
p.G646C	TCGA-FS-A1ZB	SKCM	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.25
p.G646C	DO37886	SKCM	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.25
p.R643K	DO229010	COCA	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.1667
p.R643K	DO229013	COCA	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.1667
p.R643K	DO229016	COCA	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.1667
p.R643K	DO229003	COCA	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.1667
p.R643K	DO229005	COCA	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.1667
p.R643K	DO228941	LICA	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.1667
p.R643K	DO228947	LICA	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.1667
p.T654K	DO229022	LICA	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation altering degron motif	0.6195
p.P642S	DO220903	MELA	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.1389
p.L656M	SIDM00193	Colorectal Carcinoma	GDSC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation altering degron motif	0.5999
p.L656M	ACH-000991	Colon/Colorectal Cancer	CCLE	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation altering degron motif	0.5999
p.L656M	SNU-81	large intestine	COSMIC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation altering degron motif	0.5999
p.P647A	SIDM00190	Melanoma	GDSC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.2778
p.T649S	SIDM00327	Hodgkin's Lymphoma	GDSC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation altering degron motif	0.6005
p.T649S	ACH-000754	Lymphoma	CCLE	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation altering degron motif	0.6005
p.T649S	L-428	haematopoietic and lymphoid tissue	COSMIC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation altering degron motif	0.6005
p.P658L	SIDM01073	Other Blood Cancers	GDSC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.3056
p.P658L	ACH-002242	Leukemia	CCLE	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.3056
p.P658L	HC-1	haematopoietic and lymphoid tissue	COSMIC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.3056
p.L640Q	SIDM01363	Squamous Cell Lung Carcinoma	GDSC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.0833
p.L640Q	ACH-000390	Lung Cancer	CCLE	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.0833
p.G659D	ACH-002287	Colon/Colorectal Cancer	CCLE	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.2778
p.G659D	NCI-H630	large intestine	COSMIC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.2778

Kaplan plot for TNR in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TNR

UniProt ID: Q92752

Entrez ID: 7143

Protein name: Tenascin-R (TN-R) (Janusin) (Restrictin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TNR in