DegronMD - Q92752(TNR)

FUNCTION: Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface ... View more >>

GO - Biological processes (BP): associative learning [GO:0008306]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; extracellular matrix organization [GO:0030198]; locomotory exploration behavior [GO:0035641]; long-term synaptic potentiation [GO:0060291]; negative regulation of axon extension involved in regeneration [GO:00... View more >>

GO - Molecular function (MF): signaling receptor binding [GO:0005102]

GO - Cellular component (CC): cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; membrane raft [GO:0045121]; perineuronal net [GO:0072534]; Schaffer collateral - CA1 synapse [GO:0098685]; tenasc... View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L653M	TCGA-56-7730	LUSC	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation altering degron motif	0.711
p.L653M	TCGA-FS-A1ZJ	SKCM	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation altering degron motif	0.711
p.L653M	DO26617	LUSC	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation altering degron motif	0.711
p.L653M	DO37956	SKCM	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation altering degron motif	0.711
p.T654K	DO229022	LICA	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation altering degron motif	0.6195
p.T649S	SIDM00327	Hodgkin's Lymphoma	GDSC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation altering degron motif	0.6005
p.T649S	ACH-000754	Lymphoma	CCLE	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation altering degron motif	0.6005
p.T649S	L-428	haematopoietic and lymphoid tissue	COSMIC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation altering degron motif	0.6005
p.L656M	SIDM00193	Colorectal Carcinoma	GDSC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation altering degron motif	0.5999
p.L656M	ACH-000991	Colon/Colorectal Cancer	CCLE	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation altering degron motif	0.5999
p.L656M	SNU-81	large intestine	COSMIC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation altering degron motif	0.5999
p.V657I	TCGA-DU-5870	LGG	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation altering degron motif	0.5965
p.V657I	DO22199	LGG	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation altering degron motif	0.5965
p.P658T	TCGA-17-Z022	LUAD	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.3056
p.T648I	TCGA-EE-A3AG	SKCM	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.3056
p.T648I	DO37471	SKCM	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.3056
p.P658L	SIDM01073	Other Blood Cancers	GDSC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.3056
p.P658L	ACH-002242	Leukemia	CCLE	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.3056
p.P658L	HC-1	haematopoietic and lymphoid tissue	COSMIC	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.3056
p.P647L	TCGA-EB-A3XD	SKCM	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	649:657	Mutation rewiring degron network	0.2778

Showing 1 to 20 of 52 entries

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TNR

UniProt ID: Q92752

Entrez ID: 7143

Protein name: Tenascin-R (TN-R) (Janusin) (Restrictin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TNR in