DegronMD

Uniprot ID: Q92752

Source protein: Tenascin-R

Source gene: TNR

Class: DEG_APCC_DBOX_1

Location: 649:657

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7488

ASA_SCORE: 61.1222

COIL: 0.4331

CONS_SCORE: 0.5687

DSS_SCORE: 0.3885

HELIX: 0.0038

FCONS_SCORE: 1.0289

RIG_SCORE: 0.8232

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P658T	TCGA-17-Z022	LUAD	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	0.3056
p.V664F	TCGA-39-5040	LUSC	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	0.1389
p.V664F	DO45436	LUSC	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	0.1389
p.V639L	TCGA-44-5644	LUAD	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	0.0556
p.V639L	DO25153	LUAD	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	0.0556
p.L653M	TCGA-56-7730	LUSC	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	0.711
p.L653M	TCGA-FS-A1ZJ	SKCM	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	0.711
p.L653M	DO26617	LUSC	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	0.711
p.L653M	DO37956	SKCM	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	0.711
p.G644C	TCGA-6A-AB49	LUSC	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	0.1944
p.G644C	DO52020	LUSC	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	0.1944
p.G646R	TCGA-77-6842	LUSC	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	0.25
p.G646R	DO27413	LUSC	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	0.25
p.P642T	TCGA-BK-A139	UCEC	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	0.1389
p.P642T	TCGA-NJ-A4YQ	LUAD	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	0.1389
p.P642T	DO218944	LUAD	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	0.1389
p.P642T	DO41716	UCEC	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	0.1389
p.G644D	TCGA-D3-A8GM	SKCM	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	0.1944
p.G644D	DO50288	SKCM	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	0.1944
p.V657I	TCGA-DU-5870	LGG	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	0.5965
p.V657I	DO22199	LGG	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	0.5965
p.P647L	TCGA-EB-A3XD	SKCM	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	0.2778
p.P647L	DO37871	SKCM	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	0.2778
p.G663R	TCGA-EE-A2ME	SKCM	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	0.1667
p.G663R	DO38011	SKCM	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	0.1667
p.T648I	TCGA-EE-A3AG	SKCM	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	0.3056
p.T648I	DO37471	SKCM	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	0.3056
p.G646C	TCGA-FS-A1ZB	SKCM	TCGA	TRATLTDLV	DEG_APCC_DBOX_1	0.25
p.G646C	DO37886	SKCM	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	0.25
p.R643K	DO229010	COCA	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	0.1667
p.R643K	DO229013	COCA	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	0.1667
p.R643K	DO229016	COCA	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	0.1667
p.R643K	DO229003	COCA	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	0.1667
p.R643K	DO229005	COCA	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	0.1667
p.R643K	DO228941	LICA	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	0.1667
p.R643K	DO228947	LICA	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	0.1667
p.T654K	DO229022	LICA	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	0.6195
p.P642S	DO220903	MELA	ICGC	TRATLTDLV	DEG_APCC_DBOX_1	0.1389
p.L656M	SIDM00193	Colorectal Carcinoma	GDSC	TRATLTDLV	DEG_APCC_DBOX_1	0.5999
p.L656M	ACH-000991	Colon/Colorectal Cancer	CCLE	TRATLTDLV	DEG_APCC_DBOX_1	0.5999
p.L656M	SNU-81	large_intestine	COSMIC	TRATLTDLV	DEG_APCC_DBOX_1	0.5999
p.P647A	SIDM00190	Melanoma	GDSC	TRATLTDLV	DEG_APCC_DBOX_1	0.2778
p.T649S	SIDM00327	Hodgkin's Lymphoma	GDSC	TRATLTDLV	DEG_APCC_DBOX_1	0.6005
p.T649S	ACH-000754	Lymphoma	CCLE	TRATLTDLV	DEG_APCC_DBOX_1	0.6005
p.T649S	L-428	haematopoietic_and_lymphoid_tissue	COSMIC	TRATLTDLV	DEG_APCC_DBOX_1	0.6005
p.P658L	SIDM01073	Other Blood Cancers	GDSC	TRATLTDLV	DEG_APCC_DBOX_1	0.3056
p.P658L	ACH-002242	Leukemia	CCLE	TRATLTDLV	DEG_APCC_DBOX_1	0.3056
p.P658L	HC-1	haematopoietic_and_lymphoid_tissue	COSMIC	TRATLTDLV	DEG_APCC_DBOX_1	0.3056
p.L640Q	SIDM01363	Squamous Cell Lung Carcinoma	GDSC	TRATLTDLV	DEG_APCC_DBOX_1	0.0833
p.L640Q	ACH-000390	Lung Cancer	CCLE	TRATLTDLV	DEG_APCC_DBOX_1	0.0833
p.G659D	ACH-002287	Colon/Colorectal Cancer	CCLE	TRATLTDLV	DEG_APCC_DBOX_1	0.2778
p.G659D	NCI-H630	large_intestine	COSMIC	TRATLTDLV	DEG_APCC_DBOX_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TRATLTDLV

Degron related mutations and impact score

Drug responses associated with TNR mutations

All proteins holding degron of TRATLTDLV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92752	Tenascin-R	DEG_APCC_DBOX_1	649:657	TRATLTDLV	APC,CDC20,FZR1	0.7488	More...