DegronMD - Q92802(N4BP2L2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F218C	TCGA-06-5416	GBM	TCGA	FVPFYE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.0556
p.D217A	TCGA-B5-A1MR	UCEC	TCGA	FVPFYE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.0833
p.K210E	DO514	BLCA	ICGC	FVPFYE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.2778
p.L214I	DO8842	COAD	ICGC	FVPFYE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1667
p.E195G	DO228090	EOPC	ICGC	FVPFYE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1111
p.F203C	DO10880	GBM	ICGC	FVPFYE	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.7108
p.N211S	DO16124	KIRC	ICGC	FVPFYE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.25
p.Y207C	DO23408	LINC	ICGC	FVPFYE	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.5976
p.N214S	DO50848	LIRI	ICGC	FVPFYE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1667
p.F203V	DO26710	LUSC	ICGC	FVPFYE	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.5957
p.K194E	DO32751	PAAD	ICGC	FVPFYE	LIG_APCC_ABBA_1	203:208	Mutation substituting flanking lysine	0.1944
p.K213T	DO47769	STAD	ICGC	FVPFYE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1944
p.L214R	DO50078	UCEC	ICGC	FVPFYE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1667
p.D202A	DO41758	UCEC	ICGC	FVPFYE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.3056
p.P217H	DO41572	UCEC	ICGC	FVPFYE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.0833
p.C193F	DO42889	UCEC	ICGC	FVPFYE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.0556
p.G216R	SIDM02011	Pancreatic Carcinoma	GDSC	FVPFYE	LIG_APCC_ABBA_1	203:208	Mutation blocking ubiquitination signal	0.5556
p.D195Y	SIDM00602	Gastric Carcinoma	GDSC	FVPFYE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1111
p.D195Y	IM-95	stomach	COSMIC	FVPFYE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1111
p.Q202H	SIDM01608	Endometrial Carcinoma	GDSC	FVPFYE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.3056
p.Q202H	ACH-000990	Endometrial/Uterine Cancer	CCLE	FVPFYE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.3056

Kaplan plot for N4BP2L2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

N4BP2L2

UniProt ID: Q92802

Entrez ID: 10443

Protein name: NEDD4-binding protein 2-like 2 (Phosphonoformate immuno-associated protein 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for N4BP2L2 in