DegronMD

Uniprot ID: Q92802

Source protein: NEDD4-binding protein 2-like 2

Source gene: N4BP2L2

Class: LIG_APCC_ABBA_1

Location: 203:208

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9101

ASA_SCORE: 92.85

COIL: 0.8477

CONS_SCORE: 0.3489

DSS_SCORE: 0.6041

HELIX: 0.0935

FCONS_SCORE: 1.0153

RIG_SCORE: 0.7358

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F218C	TCGA-06-5416	GBM	TCGA	FVPFYE	LIG_APCC_ABBA_1	0.0556
p.D217A	TCGA-B5-A1MR	UCEC	TCGA	FVPFYE	LIG_APCC_ABBA_1	0.0833
p.K210E	DO514	BLCA	ICGC	FVPFYE	LIG_APCC_ABBA_1	0.2778
p.L214I	DO8842	COAD	ICGC	FVPFYE	LIG_APCC_ABBA_1	0.1667
p.E195G	DO228090	EOPC	ICGC	FVPFYE	LIG_APCC_ABBA_1	0.1111
p.F203C	DO10880	GBM	ICGC	FVPFYE	LIG_APCC_ABBA_1	0.7108
p.N211S	DO16124	KIRC	ICGC	FVPFYE	LIG_APCC_ABBA_1	0.25
p.Y207C	DO23408	LINC	ICGC	FVPFYE	LIG_APCC_ABBA_1	0.5976
p.N214S	DO50848	LIRI	ICGC	FVPFYE	LIG_APCC_ABBA_1	0.1667
p.F203V	DO26710	LUSC	ICGC	FVPFYE	LIG_APCC_ABBA_1	0.5957
p.K194E	DO32751	PAAD	ICGC	FVPFYE	LIG_APCC_ABBA_1	0.1944
p.K213T	DO47769	STAD	ICGC	FVPFYE	LIG_APCC_ABBA_1	0.1944
p.L214R	DO50078	UCEC	ICGC	FVPFYE	LIG_APCC_ABBA_1	0.1667
p.D202A	DO41758	UCEC	ICGC	FVPFYE	LIG_APCC_ABBA_1	0.3056
p.P217H	DO41572	UCEC	ICGC	FVPFYE	LIG_APCC_ABBA_1	0.0833
p.C193F	DO42889	UCEC	ICGC	FVPFYE	LIG_APCC_ABBA_1	0.0556
p.G216R	SIDM02011	Pancreatic Carcinoma	GDSC	FVPFYE	LIG_APCC_ABBA_1	0.5556
p.D195Y	SIDM00602	Gastric Carcinoma	GDSC	FVPFYE	LIG_APCC_ABBA_1	0.1111
p.D195Y	IM-95	stomach	COSMIC	FVPFYE	LIG_APCC_ABBA_1	0.1111
p.Q202H	SIDM01608	Endometrial Carcinoma	GDSC	FVPFYE	LIG_APCC_ABBA_1	0.3056
p.Q202H	ACH-000990	Endometrial/Uterine Cancer	CCLE	FVPFYE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92802	NEDD4-binding protein 2-like 2	LIG_APCC_ABBA_1	203:208	FVPFYE	APC,CDC20,FZR1	0.9101	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons