DegronMD - Q92823(NRCAM)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T615M	TCGA-AP-A1E1	UCEC	TCGA	DSGTYT	DEG_SCF_TRCP1_1	610:615	Mutation altering degron motif	0.7423
p.D609N	TCGA-BR-7851	STAD	TCGA	DSGTYT	DEG_SCF_TRCP1_1	610:615	Mutation rewiring degron network	0.3056
p.D609N	TCGA-EB-A431	SKCM	TCGA	DSGTYT	DEG_SCF_TRCP1_1	610:615	Mutation rewiring degron network	0.3056
p.H600N	TCGA-ER-A19F	SKCM	TCGA	DSGTYT	DEG_SCF_TRCP1_1	610:615	Mutation rewiring degron network	0.0556
p.A623T	DO233173	GACA	ICGC	DSGTYT	DEG_SCF_TRCP1_1	610:615	Mutation rewiring degron network	0.1111
p.A623T	DO47721	STAD	ICGC	DSGTYT	DEG_SCF_TRCP1_1	610:615	Mutation rewiring degron network	0.1111
p.S605R	DO228974	LICA	ICGC	DSGTYT	DEG_SCF_TRCP1_1	610:615	Mutation rewiring degron network	0.1944
p.T609K	DO229009	LICA	ICGC	DSGTYT	DEG_SCF_TRCP1_1	610:615	Mutation rewiring degron network	0.3056
p.D603N	DO37671	SKCM	ICGC	DSGTYT	DEG_SCF_TRCP1_1	610:615	Mutation rewiring degron network	0.1389
p.D603N	DO38711	STAD	ICGC	DSGTYT	DEG_SCF_TRCP1_1	610:615	Mutation rewiring degron network	0.1389
p.T609M	DO43226	UCEC	ICGC	DSGTYT	DEG_SCF_TRCP1_1	610:615	Mutation rewiring degron network	0.3056
p.V625I	SIDM00428	Acute Myeloid Leukemia	GDSC	DSGTYT	DEG_SCF_TRCP1_1	610:615	Mutation rewiring degron network	0.0556
p.V625I	NB-4	haematopoietic and lymphoid tissue	COSMIC	DSGTYT	DEG_SCF_TRCP1_1	610:615	Mutation rewiring degron network	0.0556
p.T613I	SIDM00155	Head and Neck Carcinoma	GDSC	DSGTYT	DEG_SCF_TRCP1_1	610:615	Mutation altering degron motif	0.5966
p.T613I	PCI-38	upper aerodigestive tract	COSMIC	DSGTYT	DEG_SCF_TRCP1_1	610:615	Mutation altering degron motif	0.5966
p.N619S	SIDM00183	Small Cell Lung Carcinoma	GDSC	DSGTYT	DEG_SCF_TRCP1_1	610:615	Mutation rewiring degron network	0.2222
p.N619S	SIDM00339	Non-Small Cell Lung Carcinoma	GDSC	DSGTYT	DEG_SCF_TRCP1_1	610:615	Mutation rewiring degron network	0.2222
p.N619S	SIDM01648	Non-Cancerous	GDSC	DSGTYT	DEG_SCF_TRCP1_1	610:615	Mutation rewiring degron network	0.2222
p.P623A	ACH-000373	Leukemia	CCLE	DSGTYT	DEG_SCF_TRCP1_1	610:615	Mutation rewiring degron network	0.1111
p.P623A	SKM-1	haematopoietic and lymphoid tissue	COSMIC	DSGTYT	DEG_SCF_TRCP1_1	610:615	Mutation rewiring degron network	0.1111
p.V614L	ACH-000888	Lung Cancer	CCLE	DSGTYT	DEG_SCF_TRCP1_1	610:615	Mutation altering degron motif	0.6765
p.V614L	NCI-H1793	lung	COSMIC	DSGTYT	DEG_SCF_TRCP1_1	610:615	Mutation altering degron motif	0.6765
p.V614I	ACH-000989	Colon/Colorectal Cancer	CCLE	DSGTYT	DEG_SCF_TRCP1_1	610:615	Mutation altering degron motif	0.7076
p.V614I	SNU-175	large intestine	COSMIC	DSGTYT	DEG_SCF_TRCP1_1	610:615	Mutation altering degron motif	0.7076
p.A608T	ACH-001408	Bladder Cancer	CCLE	DSGTYT	DEG_SCF_TRCP1_1	610:615	Mutation rewiring degron network	0.2778
p.T607I	PCI-38	upper aerodigestive tract	COSMIC	DSGTYT	DEG_SCF_TRCP1_1	610:615	Mutation rewiring degron network	0.25
p.V620I	NB-4	haematopoietic and lymphoid tissue	COSMIC	DSGTYT	DEG_SCF_TRCP1_1	610:615	Mutation rewiring degron network	0.1944
p.V619I	NB-4	haematopoietic and lymphoid tissue	COSMIC	DSGTYT	DEG_SCF_TRCP1_1	610:615	Mutation rewiring degron network	0.2222
p.T608I	PCI-38	upper aerodigestive tract	COSMIC	DSGTYT	DEG_SCF_TRCP1_1	610:615	Mutation rewiring degron network	0.2778
p.V606I	NB-4	haematopoietic and lymphoid tissue	COSMIC	DSGTYT	DEG_SCF_TRCP1_1	610:615	Mutation rewiring degron network	0.2222

Kaplan plot for NRCAM in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NRCAM

UniProt ID: Q92823

Entrez ID: 4897

Protein name: Neuronal cell adhesion molecule (Nr-CAM) (Neuronal surface protein Bravo) (hBravo) (NgCAM-related cell adhesion molecule) (Ng-CAM-related)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NRCAM in