DegronMD

Uniprot ID: Q92823

Source protein: Neuronal cell adhesion molecule

Source gene: NRCAM

Class: DEG_SCF_TRCP1_1

Location: 610:615

E3 ligase: BTRC

DEGRON score: 0.6684

ASA_SCORE: 29.1167

COIL: 0.2505

CONS_SCORE: 0.6415

DSS_SCORE: 0.2935

HELIX: 0.083

FCONS_SCORE: 1.2573

RIG_SCORE: 0.7744

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T615M	TCGA-AP-A1E1	UCEC	TCGA	DSGTYT	DEG_SCF_TRCP1_1	0.7423
p.D609N	TCGA-BR-7851	STAD	TCGA	DSGTYT	DEG_SCF_TRCP1_1	0.3056
p.D609N	TCGA-EB-A431	SKCM	TCGA	DSGTYT	DEG_SCF_TRCP1_1	0.3056
p.H600N	TCGA-ER-A19F	SKCM	TCGA	DSGTYT	DEG_SCF_TRCP1_1	0.0556
p.A623T	DO233173	GACA	ICGC	DSGTYT	DEG_SCF_TRCP1_1	0.1111
p.A623T	DO47721	STAD	ICGC	DSGTYT	DEG_SCF_TRCP1_1	0.1111
p.S605R	DO228974	LICA	ICGC	DSGTYT	DEG_SCF_TRCP1_1	0.1944
p.T609K	DO229009	LICA	ICGC	DSGTYT	DEG_SCF_TRCP1_1	0.3056
p.D603N	DO37671	SKCM	ICGC	DSGTYT	DEG_SCF_TRCP1_1	0.1389
p.D603N	DO38711	STAD	ICGC	DSGTYT	DEG_SCF_TRCP1_1	0.1389
p.T609M	DO43226	UCEC	ICGC	DSGTYT	DEG_SCF_TRCP1_1	0.3056
p.V625I	SIDM00428	Acute Myeloid Leukemia	GDSC	DSGTYT	DEG_SCF_TRCP1_1	0.0556
p.V625I	NB-4	haematopoietic_and_lymphoid_tissue	COSMIC	DSGTYT	DEG_SCF_TRCP1_1	0.0556
p.T613I	SIDM00155	Head and Neck Carcinoma	GDSC	DSGTYT	DEG_SCF_TRCP1_1	0.5966
p.T613I	PCI-38	upper_aerodigestive_tract	COSMIC	DSGTYT	DEG_SCF_TRCP1_1	0.5966
p.N619S	SIDM00183	Small Cell Lung Carcinoma	GDSC	DSGTYT	DEG_SCF_TRCP1_1	0.2222
p.N619S	SIDM00339	Non-Small Cell Lung Carcinoma	GDSC	DSGTYT	DEG_SCF_TRCP1_1	0.2222
p.N619S	SIDM01648	Non-Cancerous	GDSC	DSGTYT	DEG_SCF_TRCP1_1	0.2222
p.P623A	ACH-000373	Leukemia	CCLE	DSGTYT	DEG_SCF_TRCP1_1	0.1111
p.P623A	SKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGTYT	DEG_SCF_TRCP1_1	0.1111
p.V614L	ACH-000888	Lung Cancer	CCLE	DSGTYT	DEG_SCF_TRCP1_1	0.6765
p.V614L	NCI-H1793	lung	COSMIC	DSGTYT	DEG_SCF_TRCP1_1	0.6765
p.V614I	ACH-000989	Colon/Colorectal Cancer	CCLE	DSGTYT	DEG_SCF_TRCP1_1	0.7076
p.V614I	SNU-175	large_intestine	COSMIC	DSGTYT	DEG_SCF_TRCP1_1	0.7076
p.A608T	ACH-001408	Bladder Cancer	CCLE	DSGTYT	DEG_SCF_TRCP1_1	0.2778
p.T607I	PCI-38	upper_aerodigestive_tract	COSMIC	DSGTYT	DEG_SCF_TRCP1_1	0.25
p.V620I	NB-4	haematopoietic_and_lymphoid_tissue	COSMIC	DSGTYT	DEG_SCF_TRCP1_1	0.1944
p.V619I	NB-4	haematopoietic_and_lymphoid_tissue	COSMIC	DSGTYT	DEG_SCF_TRCP1_1	0.2222
p.T608I	PCI-38	upper_aerodigestive_tract	COSMIC	DSGTYT	DEG_SCF_TRCP1_1	0.2778
p.V606I	NB-4	haematopoietic_and_lymphoid_tissue	COSMIC	DSGTYT	DEG_SCF_TRCP1_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGTYT

Degron related mutations and impact score

Drug responses associated with NRCAM mutations

All proteins holding degron of DSGTYT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92823	Neuronal cell adhesion molecule	DEG_SCF_TRCP1_1	610:615	DSGTYT	BTRC	0.6684	More...