DegronMD - Q92837(FRAT1)

FRAT1

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R251H	TCGA-A6-5661	COAD	TCGA	QRPLLGPLS	DEG_APCC_DBOX_1	233:241	Mutation rewiring degron network	0.0556
p.R251H	DO8634	COAD	ICGC	QRPLLGPLS	DEG_APCC_DBOX_1	233:241	Mutation rewiring degron network	0.0556
p.L225M	TCGA-A6-6653	COAD	TCGA	QRPLLGPLS	DEG_APCC_DBOX_1	233:241	Mutation rewiring degron network	0.1111
p.L225M	DO10373	COAD	ICGC	QRPLLGPLS	DEG_APCC_DBOX_1	233:241	Mutation rewiring degron network	0.1111
p.S249P	TCGA-B2-4102	KIRC	TCGA	QRPLLGPLS	DEG_APCC_DBOX_1	233:241	Mutation blocking phosphorylation signal	0.5556
p.S249P	DO18839	KIRC	ICGC	QRPLLGPLS	DEG_APCC_DBOX_1	233:241	Mutation blocking phosphorylation signal	0.5556
p.G238R	DO233764	GACA	ICGC	QRPLLGPLS	DEG_APCC_DBOX_1	233:241	Mutation altering degron motif	0.6457
p.R251G	DO230950	LUSC	ICGC	QRPLLGPLS	DEG_APCC_DBOX_1	233:241	Mutation rewiring degron network	0.0556
p.R251G	DO224638	LUSC	ICGC	QRPLLGPLS	DEG_APCC_DBOX_1	233:241	Mutation rewiring degron network	0.0556
p.P235R	DO220850	MELA	ICGC	QRPLLGPLS	DEG_APCC_DBOX_1	233:241	Mutation altering degron motif	0.6401
p.P235R	SIDM00793	Burkitt's Lymphoma	GDSC	QRPLLGPLS	DEG_APCC_DBOX_1	233:241	Mutation altering degron motif	0.6401
p.P250T	DO229253	THCA	ICGC	QRPLLGPLS	DEG_APCC_DBOX_1	233:241	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc