DegronMD

Uniprot ID: Q92837

Source protein: Proto-oncogene FRAT1

Source gene: FRAT1

Class: DEG_APCC_DBOX_1

Location: 233:241

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9788

ASA_SCORE: 83.4444

COIL: 0.9126

CONS_SCORE: 0.5919

DSS_SCORE: 0.5463

HELIX: 0.0282

FCONS_SCORE: 0.8802

RIG_SCORE: 0.6293

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R251H	TCGA-A6-5661	COAD	TCGA	QRPLLGPLS	DEG_APCC_DBOX_1	0.0556
p.R251H	DO8634	COAD	ICGC	QRPLLGPLS	DEG_APCC_DBOX_1	0.0556
p.L225M	TCGA-A6-6653	COAD	TCGA	QRPLLGPLS	DEG_APCC_DBOX_1	0.1111
p.L225M	DO10373	COAD	ICGC	QRPLLGPLS	DEG_APCC_DBOX_1	0.1111
p.S249P	TCGA-B2-4102	KIRC	TCGA	QRPLLGPLS	DEG_APCC_DBOX_1	0.5556
p.S249P	DO18839	KIRC	ICGC	QRPLLGPLS	DEG_APCC_DBOX_1	0.5556
p.G238R	DO233764	GACA	ICGC	QRPLLGPLS	DEG_APCC_DBOX_1	0.6457
p.R251G	DO230950	LUSC	ICGC	QRPLLGPLS	DEG_APCC_DBOX_1	0.0556
p.R251G	DO224638	LUSC	ICGC	QRPLLGPLS	DEG_APCC_DBOX_1	0.0556
p.P235R	DO220850	MELA	ICGC	QRPLLGPLS	DEG_APCC_DBOX_1	0.6401
p.P235R	SIDM00793	Burkitt's Lymphoma	GDSC	QRPLLGPLS	DEG_APCC_DBOX_1	0.6401
p.P250T	DO229253	THCA	ICGC	QRPLLGPLS	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92837	Proto-oncogene FRAT1	DEG_APCC_DBOX_1	233:241	QRPLLGPLS	APC,CDC20,FZR1	0.9788	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons