DegronMD - Q92844(TANK)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I102K	TCGA-AB-2804	LAML	TCGA	AREKLPKVR	DEG_APCC_DBOX_1	103:111	Mutation rewiring degron network	0.3056
p.I102K	DO21069	LAML	ICGC	AREKLPKVR	DEG_APCC_DBOX_1	103:111	Mutation rewiring degron network	0.3056
p.R112I	TCGA-EO-A22U	UCEC	TCGA	AREKLPKVR	DEG_APCC_DBOX_1	103:111	Mutation rewiring degron network	0.3056
p.I99T	TCGA-RM-A68T	PCPG	TCGA	AREKLPKVR	DEG_APCC_DBOX_1	103:111	Mutation rewiring degron network	0.2222
p.I99T	ACH-001532	Rhabdoid	CCLE	AREKLPKVR	DEG_APCC_DBOX_1	103:111	Mutation rewiring degron network	0.2222
p.I99T	ACH-001862	Bile Duct Cancer	CCLE	AREKLPKVR	DEG_APCC_DBOX_1	103:111	Mutation rewiring degron network	0.2222
p.L107V	DO229044	LICA	ICGC	AREKLPKVR	DEG_APCC_DBOX_1	103:111	Mutation altering degron motif	0.6765
p.Q113E	SIDM01021	Glioblastoma	GDSC	AREKLPKVR	DEG_APCC_DBOX_1	103:111	Mutation rewiring degron network	0.2778
p.Q113E	SIDM00845	Burkitt's Lymphoma	GDSC	AREKLPKVR	DEG_APCC_DBOX_1	103:111	Mutation rewiring degron network	0.2778
p.Q113E	SIDM00969	Ovarian Carcinoma	GDSC	AREKLPKVR	DEG_APCC_DBOX_1	103:111	Mutation rewiring degron network	0.2778
p.Q113E	SIDM01112	Osteosarcoma	GDSC	AREKLPKVR	DEG_APCC_DBOX_1	103:111	Mutation rewiring degron network	0.2778
p.Q113E	SIDM00650	Small Cell Lung Carcinoma	GDSC	AREKLPKVR	DEG_APCC_DBOX_1	103:111	Mutation rewiring degron network	0.2778
p.Q113E	SIDM01681	Non-Cancerous	GDSC	AREKLPKVR	DEG_APCC_DBOX_1	103:111	Mutation rewiring degron network	0.2778
p.Q113E	SIDM01173	Rhabdomyosarcoma	GDSC	AREKLPKVR	DEG_APCC_DBOX_1	103:111	Mutation rewiring degron network	0.2778
p.Q113E	SIDM01752	Pancreatic Carcinoma	GDSC	AREKLPKVR	DEG_APCC_DBOX_1	103:111	Mutation rewiring degron network	0.2778
p.A115S	SIDM00457	Plasma Cell Myeloma	GDSC	AREKLPKVR	DEG_APCC_DBOX_1	103:111	Mutation rewiring degron network	0.2222
p.A115S	OPM-2	haematopoietic and lymphoid tissue	COSMIC	AREKLPKVR	DEG_APCC_DBOX_1	103:111	Mutation rewiring degron network	0.2222
p.E101K	SNU-81	large intestine	COSMIC	AREKLPKVR	DEG_APCC_DBOX_1	103:111	Mutation rewiring degron network	0.2778
p.E102K	SNU-81	large intestine	COSMIC	AREKLPKVR	DEG_APCC_DBOX_1	103:111	Mutation rewiring degron network	0.3056

Kaplan plot for TANK in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TANK

UniProt ID: Q92844

Entrez ID: 10010

Protein name: TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TANK in