DegronMD

Uniprot ID: Q92844

Source protein: TRAF family member-associated NF-kappa-B activator

Source gene: TANK

Class: DEG_APCC_DBOX_1

Location: 103:111

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9852

ASA_SCORE: 97.3556

COIL: 0.4126

CONS_SCORE: 0.4481

DSS_SCORE: 0.5478

HELIX: 0.5526

FCONS_SCORE: 1.0412

RIG_SCORE: 0.7358

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I102K	TCGA-AB-2804	LAML	TCGA	AREKLPKVR	DEG_APCC_DBOX_1	0.3056
p.I102K	DO21069	LAML	ICGC	AREKLPKVR	DEG_APCC_DBOX_1	0.3056
p.R112I	TCGA-EO-A22U	UCEC	TCGA	AREKLPKVR	DEG_APCC_DBOX_1	0.3056
p.I99T	TCGA-RM-A68T	PCPG	TCGA	AREKLPKVR	DEG_APCC_DBOX_1	0.2222
p.I99T	ACH-001532	Rhabdoid	CCLE	AREKLPKVR	DEG_APCC_DBOX_1	0.2222
p.I99T	ACH-001862	Bile Duct Cancer	CCLE	AREKLPKVR	DEG_APCC_DBOX_1	0.2222
p.L107V	DO229044	LICA	ICGC	AREKLPKVR	DEG_APCC_DBOX_1	0.6765
p.Q113E	SIDM01021	Glioblastoma	GDSC	AREKLPKVR	DEG_APCC_DBOX_1	0.2778
p.Q113E	SIDM00845	Burkitt's Lymphoma	GDSC	AREKLPKVR	DEG_APCC_DBOX_1	0.2778
p.Q113E	SIDM00969	Ovarian Carcinoma	GDSC	AREKLPKVR	DEG_APCC_DBOX_1	0.2778
p.Q113E	SIDM01112	Osteosarcoma	GDSC	AREKLPKVR	DEG_APCC_DBOX_1	0.2778
p.Q113E	SIDM00650	Small Cell Lung Carcinoma	GDSC	AREKLPKVR	DEG_APCC_DBOX_1	0.2778
p.Q113E	SIDM01681	Non-Cancerous	GDSC	AREKLPKVR	DEG_APCC_DBOX_1	0.2778
p.Q113E	SIDM01173	Rhabdomyosarcoma	GDSC	AREKLPKVR	DEG_APCC_DBOX_1	0.2778
p.Q113E	SIDM01752	Pancreatic Carcinoma	GDSC	AREKLPKVR	DEG_APCC_DBOX_1	0.2778
p.A115S	SIDM00457	Plasma Cell Myeloma	GDSC	AREKLPKVR	DEG_APCC_DBOX_1	0.2222
p.A115S	OPM-2	haematopoietic_and_lymphoid_tissue	COSMIC	AREKLPKVR	DEG_APCC_DBOX_1	0.2222
p.E101K	SNU-81	large_intestine	COSMIC	AREKLPKVR	DEG_APCC_DBOX_1	0.2778
p.E102K	SNU-81	large_intestine	COSMIC	AREKLPKVR	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92844	TRAF family member-associated NF-kappa-B activator	DEG_APCC_DBOX_1	103:111	AREKLPKVR	APC,CDC20,FZR1	0.9852	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons