DegronMD - Q92915(FGF14)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T229M	TCGA-02-2470	GBM	TCGA	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.3056
p.T229M	TCGA-32-1970	GBM	TCGA	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.3056
p.T229M	TCGA-C5-A7CG	CESC	TCGA	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.3056
p.T229M	TCGA-E1-A7YN	LGG	TCGA	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.3056
p.T229M	TCGA-L5-A4OG	ESCA	TCGA	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.3056
p.T229M	TCGA-VS-A94Z	CESC	TCGA	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.3056
p.R212Q	TCGA-AA-3666	COAD	TCGA	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.0833
p.R212Q	TCGA-EO-A3B0	UCEC	TCGA	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.0833
p.A236V	TCGA-AA-3715	COAD	TCGA	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.1111
p.A236V	TCGA-AA-3949	COAD	TCGA	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.1111
p.A236V	TCGA-B5-A3FA	UCEC	TCGA	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.1111
p.T222M	TCGA-BR-4361	STAD	TCGA	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation altering degron motif	0.7423
p.A238V	TCGA-D1-A103	UCEC	TCGA	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.0556
p.T222A	TCGA-EO-A3KX	UCEC	TCGA	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation altering degron motif	0.7139
p.L216W	TCGA-QF-A5YS	UCEC	TCGA	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.1944
p.T224M	DO49884	CESC	ICGC	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation altering degron motif	0.7423
p.T224M	DO51634	CESC	ICGC	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation altering degron motif	0.7423
p.T224M	DO13516	GBM	ICGC	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation altering degron motif	0.7423
p.T224M	DO13144	GBM	ICGC	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation altering degron motif	0.7423
p.T224M	DO223671	LGG	ICGC	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation altering degron motif	0.7423
p.A231V	DO8018	COAD	ICGC	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.25
p.A231V	DO7798	COAD	ICGC	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.25
p.A231V	DO52402	UCEC	ICGC	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.25
p.A231V	ACH-000836	Head and Neck Cancer	CCLE	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.25
p.A233E	DO229019	LICA	ICGC	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.1944
p.E216K	DO220876	MELA	ICGC	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.1944
p.E216K	DO222542	MELA	ICGC	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.1944
p.G237E	DO51275	SKCM	ICGC	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.0833
p.T217M	DO38887	STAD	ICGC	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.2222
p.T217A	DO219774	UCEC	ICGC	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.2222
p.A233V	DO42312	UCEC	ICGC	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.1944
p.L211W	DO52426	UCEC	ICGC	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.0556
p.P224T	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation altering degron motif	0.7031
p.P224T	NCI-H2126	lung	COSMIC	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation altering degron motif	0.7031
p.P219T	ACH-000785	Lung Cancer	CCLE	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.2778
p.P219T	NCI-H2126	lung	COSMIC	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.2778
p.D213N	ACH-001982	Metastasis	CCLE	PGVTPSKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FGF14

UniProt ID: Q92915

Entrez ID: 2259

Protein name: Fibroblast growth factor 14 (FGF-14) (Fibroblast growth factor homologous factor 4) (FHF-4)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for FGF14 in