DegronMD

Uniprot ID: Q92915

Source protein: Fibroblast growth factor 14

Source gene: FGF14

Class: DEG_SCF_FBW7_1

Location: 221:228

E3 ligase: FBXW7

DEGRON score: 0.9987

ASA_SCORE: 87.85

COIL: 0.9625

CONS_SCORE: 0.6722

DSS_SCORE: 0.6116

HELIX: 0.0224

FCONS_SCORE: 0.994

RIG_SCORE: 0.6319

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T229M	TCGA-02-2470	GBM	TCGA	PGVTPSKS	DEG_SCF_FBW7_1	0.3056
p.T229M	TCGA-32-1970	GBM	TCGA	PGVTPSKS	DEG_SCF_FBW7_1	0.3056
p.T229M	TCGA-C5-A7CG	CESC	TCGA	PGVTPSKS	DEG_SCF_FBW7_1	0.3056
p.T229M	TCGA-E1-A7YN	LGG	TCGA	PGVTPSKS	DEG_SCF_FBW7_1	0.3056
p.T229M	TCGA-L5-A4OG	ESCA	TCGA	PGVTPSKS	DEG_SCF_FBW7_1	0.3056
p.T229M	TCGA-VS-A94Z	CESC	TCGA	PGVTPSKS	DEG_SCF_FBW7_1	0.3056
p.R212Q	TCGA-AA-3666	COAD	TCGA	PGVTPSKS	DEG_SCF_FBW7_1	0.0833
p.R212Q	TCGA-EO-A3B0	UCEC	TCGA	PGVTPSKS	DEG_SCF_FBW7_1	0.0833
p.A236V	TCGA-AA-3715	COAD	TCGA	PGVTPSKS	DEG_SCF_FBW7_1	0.1111
p.A236V	TCGA-AA-3949	COAD	TCGA	PGVTPSKS	DEG_SCF_FBW7_1	0.1111
p.A236V	TCGA-B5-A3FA	UCEC	TCGA	PGVTPSKS	DEG_SCF_FBW7_1	0.1111
p.T222M	TCGA-BR-4361	STAD	TCGA	PGVTPSKS	DEG_SCF_FBW7_1	0.7423
p.A238V	TCGA-D1-A103	UCEC	TCGA	PGVTPSKS	DEG_SCF_FBW7_1	0.0556
p.T222A	TCGA-EO-A3KX	UCEC	TCGA	PGVTPSKS	DEG_SCF_FBW7_1	0.7139
p.L216W	TCGA-QF-A5YS	UCEC	TCGA	PGVTPSKS	DEG_SCF_FBW7_1	0.1944
p.T224M	DO49884	CESC	ICGC	PGVTPSKS	DEG_SCF_FBW7_1	0.7423
p.T224M	DO51634	CESC	ICGC	PGVTPSKS	DEG_SCF_FBW7_1	0.7423
p.T224M	DO13516	GBM	ICGC	PGVTPSKS	DEG_SCF_FBW7_1	0.7423
p.T224M	DO13144	GBM	ICGC	PGVTPSKS	DEG_SCF_FBW7_1	0.7423
p.T224M	DO223671	LGG	ICGC	PGVTPSKS	DEG_SCF_FBW7_1	0.7423
p.A231V	DO8018	COAD	ICGC	PGVTPSKS	DEG_SCF_FBW7_1	0.25
p.A231V	DO7798	COAD	ICGC	PGVTPSKS	DEG_SCF_FBW7_1	0.25
p.A231V	DO52402	UCEC	ICGC	PGVTPSKS	DEG_SCF_FBW7_1	0.25
p.A231V	ACH-000836	Head and Neck Cancer	CCLE	PGVTPSKS	DEG_SCF_FBW7_1	0.25
p.A233E	DO229019	LICA	ICGC	PGVTPSKS	DEG_SCF_FBW7_1	0.1944
p.E216K	DO220876	MELA	ICGC	PGVTPSKS	DEG_SCF_FBW7_1	0.1944
p.E216K	DO222542	MELA	ICGC	PGVTPSKS	DEG_SCF_FBW7_1	0.1944
p.G237E	DO51275	SKCM	ICGC	PGVTPSKS	DEG_SCF_FBW7_1	0.0833
p.T217M	DO38887	STAD	ICGC	PGVTPSKS	DEG_SCF_FBW7_1	0.2222
p.T217A	DO219774	UCEC	ICGC	PGVTPSKS	DEG_SCF_FBW7_1	0.2222
p.A233V	DO42312	UCEC	ICGC	PGVTPSKS	DEG_SCF_FBW7_1	0.1944
p.L211W	DO52426	UCEC	ICGC	PGVTPSKS	DEG_SCF_FBW7_1	0.0556
p.P224T	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	PGVTPSKS	DEG_SCF_FBW7_1	0.7031
p.P224T	NCI-H2126	lung	COSMIC	PGVTPSKS	DEG_SCF_FBW7_1	0.7031
p.P219T	ACH-000785	Lung Cancer	CCLE	PGVTPSKS	DEG_SCF_FBW7_1	0.2778
p.P219T	NCI-H2126	lung	COSMIC	PGVTPSKS	DEG_SCF_FBW7_1	0.2778
p.D213N	ACH-001982	Metastasis	CCLE	PGVTPSKS	DEG_SCF_FBW7_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGVTPSKS

Degron related mutations and impact score

Drug responses associated with FGF14 mutations

All proteins holding degron of PGVTPSKS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92915	Fibroblast growth factor 14	DEG_SCF_FBW7_1	221:228	PGVTPSKS	FBXW7	0.9987	More...