DegronMD - Q92974(ARHGEF2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L687M	TCGA-AB-2828	LAML	TCGA	DSGGNTS	DEG_SCF_TRCP1_1	690:696	Mutation rewiring degron network	0.25
p.T695M	TCGA-AX-A2HD	UCEC	TCGA	DSGGNTS	DEG_SCF_TRCP1_1	690:696	Mutation altering degron motif	0.7423
p.P697L	TCGA-DA-A95V	SKCM	TCGA	DSGGNTS	DEG_SCF_TRCP1_1	690:696	Mutation rewiring degron network	0.3056
p.P697A	TCGA-DA-A95V	SKCM	TCGA	DSGGNTS	DEG_SCF_TRCP1_1	690:696	Mutation rewiring degron network	0.3056
p.L688M	DO21571	LAML	ICGC	DSGGNTS	DEG_SCF_TRCP1_1	690:696	Mutation rewiring degron network	0.2778
p.T680K	DO228952	LICA	ICGC	DSGGNTS	DEG_SCF_TRCP1_1	690:696	Mutation rewiring degron network	0.0556
p.S692R	DO229015	LICA	ICGC	DSGGNTS	DEG_SCF_TRCP1_1	690:696	Mutation altering degron motif	0.7427
p.P687T	DO232761	PBCA	ICGC	DSGGNTS	DEG_SCF_TRCP1_1	690:696	Mutation rewiring degron network	0.25
p.P698A	DO219478	SKCM	ICGC	DSGGNTS	DEG_SCF_TRCP1_1	690:696	Mutation rewiring degron network	0.2778
p.P698L	DO219478	SKCM	ICGC	DSGGNTS	DEG_SCF_TRCP1_1	690:696	Mutation rewiring degron network	0.2778
p.T696M	DO42608	UCEC	ICGC	DSGGNTS	DEG_SCF_TRCP1_1	690:696	Mutation altering degron motif	0.7423
p.G692S	SIDM01016	T-Lymphoblastic Leukemia	GDSC	DSGGNTS	DEG_SCF_TRCP1_1	690:696	Mutation altering degron motif	0.6993
p.G692S	ACH-000995	Leukemia	CCLE	DSGGNTS	DEG_SCF_TRCP1_1	690:696	Mutation altering degron motif	0.6993
p.G692S	Jurkat	haematopoietic and lymphoid tissue	COSMIC	DSGGNTS	DEG_SCF_TRCP1_1	690:696	Mutation altering degron motif	0.6993
p.G691S	Jurkat	haematopoietic and lymphoid tissue	COSMIC	DSGGNTS	DEG_SCF_TRCP1_1	690:696	Mutation altering degron motif	0.6993
p.R705H	SNU-1040	large intestine	COSMIC	DSGGNTS	DEG_SCF_TRCP1_1	690:696	Mutation rewiring degron network	0.0833
p.N681I	MIA-PaCa-2	pancreas	COSMIC	DSGGNTS	DEG_SCF_TRCP1_1	690:696	Mutation rewiring degron network	0.0833
p.R695C	PC-14	lung	COSMIC	DSGGNTS	DEG_SCF_TRCP1_1	690:696	Mutation altering degron motif	0.8301
p.L691P	NCI-SNU-1	stomach	COSMIC	DSGGNTS	DEG_SCF_TRCP1_1	690:696	Mutation altering degron motif	0.7582

Kaplan plot for ARHGEF2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGEF2

UniProt ID: Q92974

Entrez ID: 9181

Protein name: Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARHGEF2 in