DegronMD

Uniprot ID: Q92974

Source protein: Rho guanine nucleotide exchange factor 2

Source gene: ARHGEF2

Class: DEG_SCF_TRCP1_1

Location: 690:696

E3 ligase: BTRC

DEGRON score: 0.999

ASA_SCORE: 66.4

COIL: 0.9417

CONS_SCORE: 0.5019

DSS_SCORE: 0.6831

HELIX: 0.0266

FCONS_SCORE: 1.0938

RIG_SCORE: 0.5617

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L687M	TCGA-AB-2828	LAML	TCGA	DSGGNTS	DEG_SCF_TRCP1_1	0.25
p.T695M	TCGA-AX-A2HD	UCEC	TCGA	DSGGNTS	DEG_SCF_TRCP1_1	0.7423
p.P697L	TCGA-DA-A95V	SKCM	TCGA	DSGGNTS	DEG_SCF_TRCP1_1	0.3056
p.P697A	TCGA-DA-A95V	SKCM	TCGA	DSGGNTS	DEG_SCF_TRCP1_1	0.3056
p.L688M	DO21571	LAML	ICGC	DSGGNTS	DEG_SCF_TRCP1_1	0.2778
p.T680K	DO228952	LICA	ICGC	DSGGNTS	DEG_SCF_TRCP1_1	0.0556
p.S692R	DO229015	LICA	ICGC	DSGGNTS	DEG_SCF_TRCP1_1	0.7427
p.P687T	DO232761	PBCA	ICGC	DSGGNTS	DEG_SCF_TRCP1_1	0.25
p.P698A	DO219478	SKCM	ICGC	DSGGNTS	DEG_SCF_TRCP1_1	0.2778
p.P698L	DO219478	SKCM	ICGC	DSGGNTS	DEG_SCF_TRCP1_1	0.2778
p.T696M	DO42608	UCEC	ICGC	DSGGNTS	DEG_SCF_TRCP1_1	0.7423
p.G692S	SIDM01016	T-Lymphoblastic Leukemia	GDSC	DSGGNTS	DEG_SCF_TRCP1_1	0.6993
p.G692S	ACH-000995	Leukemia	CCLE	DSGGNTS	DEG_SCF_TRCP1_1	0.6993
p.G692S	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	DSGGNTS	DEG_SCF_TRCP1_1	0.6993
p.G691S	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	DSGGNTS	DEG_SCF_TRCP1_1	0.6993
p.R705H	SNU-1040	large_intestine	COSMIC	DSGGNTS	DEG_SCF_TRCP1_1	0.0833
p.N681I	MIA-PaCa-2	pancreas	COSMIC	DSGGNTS	DEG_SCF_TRCP1_1	0.0833
p.R695C	PC-14	lung	COSMIC	DSGGNTS	DEG_SCF_TRCP1_1	0.8301
p.L691P	NCI-SNU-1	stomach	COSMIC	DSGGNTS	DEG_SCF_TRCP1_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92974	Rho guanine nucleotide exchange factor 2	DEG_SCF_TRCP1_1	690:696	DSGGNTS	BTRC	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons