DegronMD - Q92985(IRF7)

IRF7

Please click HERE for better display.

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R382W	TCGA-55-8506	LUAD	TCGA	KCKVYWE	LIG_APCC_ABBAyCdc20_2	373:379	Mutation rewiring degron network	0.25
p.Q365P	DO233855	GACA	ICGC	KCKVYWE	LIG_APCC_ABBAyCdc20_2	373:379	Mutation rewiring degron network	0.1111
p.E379K	DO14426	HNSC	ICGC	KCKVYWE	LIG_APCC_ABBAyCdc20_2	373:379	Mutation altering degron motif	0.7022
p.G381D	DO14180	HNSC	ICGC	KCKVYWE	LIG_APCC_ABBAyCdc20_2	373:379	Mutation rewiring degron network	0.2778
p.R369W	DO45390	LUAD	ICGC	KCKVYWE	LIG_APCC_ABBAyCdc20_2	373:379	Mutation rewiring degron network	0.2222
p.W378L	DO37651	SKCM	ICGC	KCKVYWE	LIG_APCC_ABBAyCdc20_2	373:379	Mutation altering degron motif	0.5904
p.W378L	DO37407	SKCM	ICGC	KCKVYWE	LIG_APCC_ABBAyCdc20_2	373:379	Mutation altering degron motif	0.5904
p.G385S	DO37531	SKCM	ICGC	KCKVYWE	LIG_APCC_ABBAyCdc20_2	373:379	Mutation rewiring degron network	0.1667
p.R370H	DO41199	UCEC	ICGC	KCKVYWE	LIG_APCC_ABBAyCdc20_2	373:379	Mutation rewiring degron network	0.25
p.W378R	KM-H2	haematopoietic and lymphoid tissue	COSMIC	KCKVYWE	LIG_APCC_ABBAyCdc20_2	373:379	Mutation altering degron motif	0.7523
p.I386F	Raji	haematopoietic and lymphoid tissue	COSMIC	KCKVYWE	LIG_APCC_ABBAyCdc20_2	373:379	Mutation rewiring degron network	0.1389

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc