DegronMD

Uniprot ID: Q92985

Source protein: Interferon regulatory factor 7

Source gene: IRF7

Class: LIG_APCC_ABBAyCdc20_2

Location: 373:379

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7708

ASA_SCORE: 46.0714

COIL: 0.2756

CONS_SCORE: 0.6669

DSS_SCORE: 0.2678

HELIX: 0.0119

FCONS_SCORE: 1.4128

RIG_SCORE: 0.8237

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R382W	TCGA-55-8506	LUAD	TCGA	KCKVYWE	LIG_APCC_ABBAyCdc20_2	0.25
p.Q365P	DO233855	GACA	ICGC	KCKVYWE	LIG_APCC_ABBAyCdc20_2	0.1111
p.E379K	DO14426	HNSC	ICGC	KCKVYWE	LIG_APCC_ABBAyCdc20_2	0.7022
p.G381D	DO14180	HNSC	ICGC	KCKVYWE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R369W	DO45390	LUAD	ICGC	KCKVYWE	LIG_APCC_ABBAyCdc20_2	0.2222
p.W378L	DO37651	SKCM	ICGC	KCKVYWE	LIG_APCC_ABBAyCdc20_2	0.5904
p.W378L	DO37407	SKCM	ICGC	KCKVYWE	LIG_APCC_ABBAyCdc20_2	0.5904
p.G385S	DO37531	SKCM	ICGC	KCKVYWE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R370H	DO41199	UCEC	ICGC	KCKVYWE	LIG_APCC_ABBAyCdc20_2	0.25
p.W378R	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	KCKVYWE	LIG_APCC_ABBAyCdc20_2	0.7523
p.I386F	Raji	haematopoietic_and_lymphoid_tissue	COSMIC	KCKVYWE	LIG_APCC_ABBAyCdc20_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92985	Interferon regulatory factor 7	LIG_APCC_ABBAyCdc20_2	373:379	KCKVYWE	APC,CDC20,FZR1	0.7708	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons